Potential responders to anticancer therapy for colorectal cancer by predictor genes
Project/Area Number |
23591972
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Nihon University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 大腸がん / マイクロアレイ / 薬剤感受性 / 遺伝子プロファイル / 機械学習法 / 個別化医療 / 切除不能大腸癌 / FOLFOX / ランダムフォレスト / 遺伝子発現解析 / 癌 / 核酸 / 薬剤反応性 / 遺伝子 |
Research Abstract |
To establish the procedures to identify responders to FOLFOX therapy, 83 colorectal cancer (CRC) patients including 42 responders and 41 non-responders were divided into training (54 patients) and test (29 patients) sets. Using Random Forests (RF) algorithm in the training set, predictor genes for FOLFOX therapy were identified, which were applied to test samplesIn the training set, 22 of 27 responders (81.4%) and 23 of 27 non-responders (85.1%) were correctly classified. To improve the prediction model, we removed the outliers determined by RF, and the model could correctly classify 21 of 23 responders (91.3%) and 22 of 23 non-responders (95.6%) in the training set, and 80.0% sensitivity and 92.8% specificity, with an accuracy of 69.2% in 29 independent test samples. RF on gene-expression data for CRC patients was effectively able to stratify responders to FOLFOX therapy, and use of pharmacogenomics in anticancer therapy is the first step in planning personalised therapy.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Mechanistic background and clinical applications of indocyanine green-fluorescence imaging of hepatocellular carcinoma Short running head : ICG-fluorescence imaging of HCC2014
Author(s)
Ishizawa T, Masuda K, Urano Y, Kawaguchi Y, Satou S, Kaneko J, Hasegawa K, Shibahara J, Fukayama M, Tsuji S, Midorikawa Y, Aburatani H, Kokudo N.
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Journal Title
Ann Surg Oncol
Volume: 21
Pages: 440-8
Related Report
Peer Reviewed
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[Journal Article] Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma.2014
Author(s)
Ishizawa T, Masuda K, Urano Y, Kawaguchi Y, Satou S, Kaneko J, Hasegawa K, Shibahara J, Fukayama M, Tsuji S, Midorikawa Y, Aburatani H, Kokudo N.
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Journal Title
Ann Surg Oncol.
Volume: 21
Issue: 2
Pages: 440-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT42013
Author(s)
Kurabe N, Hayasaka T, Ogawa M, Masaki N, Yoshimi Ide Y, Waki M, Nakamura T, Kurachi K, Kahyo T, Shinmura K, Midorikawa Y, Sugiyama Y, Setou M, Sugimura H.
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Journal Title
Cancer Sci.
Volume: 104
Pages: 1295-302
Related Report
Peer Reviewed
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[Journal Article] Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.2013
Author(s)
Kurabe N, Hayasaka T, Ogawa M, Masaki N, Yoshimi Ide Y, Waki M, Nakamura T, Kurachi K, Kahyo T, Shinmura K, Midorikawa Y, Sugiyama Y, Setou M, Sugimura H.
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Journal Title
Cancer Sci
Volume: 104
Issue: 10
Pages: 1295-1302
DOI
Related Report
Peer Reviewed
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[Journal Article] Post-transcriptional regulation of p21 in the determination of p53-dependent cellular fate by the tumor-suppressor miR-222011
Author(s)
Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H.
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Journal Title
Cancer Res.
Volume: 71
Pages: 4628-39
Related Report
Peer Reviewed
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[Journal Article] Tissue-specific demethylation in CpG-poor promoters during cellular differentiation2011
Author(s)
Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H.
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Journal Title
Hum Mol Genet
Volume: 20
Pages: 2710-21
Related Report
Peer Reviewed
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[Journal Article] Post-transcriptional regulation of p21 in the determination of p53-dependent cellular fate by the tumor-suppressor miR-22.2011
Author(s)
Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H
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Journal Title
Cancer Resarch
Volume: 71
Pages: 4628-4639
Related Report
Peer Reviewed
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[Presentation] Genome-wide analysis of stepwise hepatocarcinogenesis using next generation sequencer2013
Author(s)
Midorikawa Y, Yamamoto S, Ueda H, Sonoda K, Tsuji S, Tatsuno K, Shibata T, Covington K, Morgan M, Wheeler D, Takayama T, Aburatani H.
Organizer
AASLD The Liver Meeting
Place of Presentation
Washington DC
Year and Date
2013-11-02
Related Report
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[Presentation] Genome-wide analysis of stepwise hepatocarcinogenesis using next generation sequencer2013
Author(s)
Midorikawa Y, Takayama T, Yamamoto S, Ueda H, Sonoda K, Takane K, Tsuji S, Nagae G, Tatsuno K, Morgan M, Wheeler D, Aburatani H.
Organizer
104th, American Association for Cancer Research
Place of Presentation
Washington DC
Year and Date
2013-04-09
Related Report
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