| Project/Area Number |
23591974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMITA Naohiro 兵庫医科大学, 医学部, 教授 (00252643)
IKEUCHI Hiroki 兵庫医科大学, 医学部, 教授 (80319863)
YAMANO Tomoki 兵庫医科大学, 医学部, 講師 (00599318)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ulcerative colitis / colitic cancer / eigenetic / methylation / biomarker / 潰瘍性大腸炎 / 大腸癌 / epigenetic / メチル化 |
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| Research Abstract |
Molecular carcinogenesis of colorectal cancer is well studied among other cancers in the world. Recent analysis of colorectal cancer by next generation sequencing showed the frequencies of gene alterations in the signal transductions, showing that driver genes responsible for the carcinogenesis found in NGS is no different from conventional studies. On the other hand, molecular mechanism of carcinogenesis of rare but important colorectal cancer like that based on the inflammatory bowel disease is completely unknown. There were several reports concerning abnormal promoter hyper methylation of several loci caused by exposure of chronic inflammation. Accordingly, we studied the whole genome methylation of colitic cancers compare with 2 types of sporadic colorectal cancers. As the result we found completely different methylation patters between colitic cancer and other sporadic cancers. We are now elucidating the responsible genes and mechanism of novel carcinogenesis of colitic cancer.
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