Analysis of amino acid-signal transduction in the intestinal system, applying a new nipple-bottle feeding system and artificial milk formula for newborn mice.

Research Project

Project/Area Number	23591976
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Kawasaki Medical School
Principal Investigator	YOSHIDA KAZUHIRO 川崎医科大学, 医学部, 講師 (10220633)
Co-Investigator(Kenkyū-buntansha)	YAMATSUJI Tomoki 川崎医科大学, 医学部, 准教授 (40379730)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	アミノ酸 / 腸管細胞増殖因子 / 小腸大腸肛門外科学
Research Abstract	We have presented that feeding neonatal mice with glutamine-deleted artificial milk formula induced high incidence of colonic hemorrhage due to the epithelial cell death, applying a new nipple-bottle feeding system for newborn mice. IEC6 rat intestinal epithelial cells cultured with low concentration of glutamine underwent apoptosis. Glutamine deprivation might cause instability of the intestinal epithelial alignment by apoptosis.

Report

(4 results)