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An analysis of intrahepatic lymphatic invasion in the patient with intrahepatic cholangiocarcinoma

Research Project

Project/Area Number 23591979
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionAkita University

Principal Investigator

UCHINAMI Hiroshi  秋田大学, 医学(系)研究科(研究院), 准教授 (40400486)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Yuzo  秋田大学, 大学院医学系研究科, 教授 (70281730)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝内胆管癌 / リンパ節転移 / リンパ節郭清 / 肝切除 / 外科治療
Research Abstract

Intrahepatic cholangiocarcinoma (ICC) arising from the intrahepatic bile duct is the second most frequent hepatic malignancy. Lymph node metastasis is known to be one of strong prognostic factors for survival in the patients undergoing curative resection for ICC. Therefore, the value of lymph node dissection during surgical treatment for ICC or indication of the resection for the patients who are preoperatively diagnosed to have metastatic lymph nodes is still in debate.
In this study, we evaluated correlation between intrahepatic lymph vessel invasion and lymph node metastasis. We also investigated the outcomes of ICC patients following curative resection to analyze the influences of lymph node dissection on survival and recurrence.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (12 results)

  • [Journal Article] Nrf2 activation protects the liver from ischemia/reperfusion injury in mice2014

    • Author(s)
      Kudoh K, Uchinami H, Yoshioka M, Seki E, Yamamoto Y.
    • Journal Title

      Ann Surg

      Volume: 260(1) Pages: 118-127

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognosis analysis of sarcomatous intrahepatic cholangiocarcinoma from a view of the literature2014

    • Author(s)
      Watanabe G, Uchinami H, Yoshioka M, Nanjo H, Yamamoto Y
    • Journal Title

      International journal of clinical oncology

      Volume: 印刷中 Issue: 3 Pages: 490-496

    • DOI

      10.1007/s10147-013-0586-x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 activation protects the liver from ischemia-reperfusion injury in mice2014

    • Author(s)
      Kudoh K, Uchinami H, Seki E, Yamamoto Y
    • Journal Title

      Annals of Surgery

      Volume: 印刷中 Issue: 1 Pages: 118-127

    • DOI

      10.1097/sla.0000000000000287

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-Weighted MRI for differential diagnosis in gallbladder lesions with special reference to ADC cut-off value2013

    • Author(s)
      Yoshioka M, Watanabe G, Uchinami H, Miyazawa H, Abe Y, Ishiyama K, Hashimoto M, Nakamura A, Yamamoto Y.
    • Journal Title

      Hepatogastroenterology

      Volume: 60(124) Pages: 692-698

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weighted MRI for differential diagnosis in gallbladder lesions with special reference to ADC cut-off value2013

    • Author(s)
      Yoshioka M, Watanabe G, Uchinami H, Miyazawa H, Abe Y, Ishiyama K, Hashimoto M, Nakamura A, Yamamoto Y
    • Journal Title

      Hepatogastroenterology

      Volume: 60(124) Pages: 692-698

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes2012

    • Author(s)
      Abe Y, Uchinami H, Kudoh K, Nakagawa Y, Ise N, Watanabe G, Sato T, Seki E, Yamamoto Y.
    • Journal Title

      Surgery

      Volume: 152(5) Pages: 869-878

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of liver regeneration by adenosine triphosphate-sensitive K-channel opener (diazoxide) after partial hepatectomy2012

    • Author(s)
      Nakagawa Y, Yoshioka M, Abe Y, Uchinami H, Ohba T, Ono K, Yamamoto Y.
    • Journal Title

      Transplantation

      Volume: 93(11) Pages: 1094-1100

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transfection of naked nuclear factor-kB decoy oligodeoxynucleotides into liver by rapid portal vein infusion in rats : its effect on ischemia-reperfusion injury of liver2012

    • Author(s)
      Watanabe G, Uchinami H, Yoshioka M, Abe Y, Kikuchi I, Iwasaki W, Kume M, Yamamoto Y.
    • Journal Title

      Hum Gene Ther

      Volume: 23(4) Pages: 428-436

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes2012

    • Author(s)
      Yuki Abe, Hiroshi Uchinami et al
    • Journal Title

      Surgery

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 胆管細胞癌の治療成績-胆管細胞癌切除例からみたリンパ節郭清の意義と補助化学療法の効果2013

    • Author(s)
      打波宇、吉岡政人、渡辺剛、阿部ゆき、山本雄造
    • Organizer
      第25回日本肝胆膵外科学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Final Research Report
  • [Presentation] 門脈内急速投与によるオリゴヌクレオチド肝導入方法の確立2013

    • Author(s)
      渡辺 剛、打波 宇、吉岡政人、阿部ゆき、山本雄造
    • Organizer
      第113回日本外科学会的学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膵頭十二指腸切除後膵液瘻の重症化予測とその対策2013

    • Author(s)
      打波 宇、吉岡政人、渡辺 剛、阿部ゆき、高橋智和、高橋香奈、安藤秀明、山本雄造
    • Organizer
      第113回日本外科学会的学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胆管細胞癌の治療成績 胆管細胞癌切除例からみたリンパ節郭清の意義と補助化学療法の効果2013

    • Author(s)
      打波 宇、吉岡政人、渡辺 剛、阿部ゆき、山本雄造
    • Organizer
      第25回日本肝胆膵外科学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Annual Research Report
  • [Presentation] 興味深い転移形態を示した胆嚢腺扁平上皮癌の1剖検例2013

    • Author(s)
      阿部ゆき、打波 宇、山本雄造
    • Organizer
      第25回日本肝胆膵外科学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Annual Research Report
  • [Presentation] 術後早期の膵空腸吻合部CT所見とドレーン排液アミラーゼ値からみた膵液瘻の転帰予測2013

    • Author(s)
      打波 宇、吉岡政人、渡辺 剛、阿部ゆき、高橋智和、山本雄造
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病は肝細胞癌切除症例の予後に影響をおよぼすか?2013

    • Author(s)
      渡辺 剛、打波 宇、吉岡政人、阿部ゆき、山本雄造
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胆管細胞癌切除例からみたリンパ節郭清の意義と補助化学療法の効果2013

    • Author(s)
      打波 宇
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      栃木
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝内胆管癌切除例からみた治療戦略の検討2012

    • Author(s)
      打波宇、渡辺剛、吉岡政人、阿部ゆき、高橋智和、安藤秀明、山本雄造
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 肝虚血再灌流障害に対しNrf2は保護的に働く2012

    • Author(s)
      工藤和大、打波宇、山本雄造
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2013 Final Research Report
  • [Presentation] 右側肝円索を伴った肝内胆管癌に対する肝左3区域切除2012

    • Author(s)
      打波宇、阿部ゆき、渡辺剛、吉岡政人、山本雄造
    • Organizer
      第24回日本肝胆膵外科学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 中下部胆管癌切除症例の再発形式からみた至適リンパ節郭清範囲の検討2012

    • Author(s)
      打波宇、吉岡政人、渡辺剛、阿部ゆき、高橋智和、安藤秀明、山本雄造
    • Organizer
      第112回日本外科学会定期学術首魁
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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