Development of new therapy of hepatocellular carcinoma by splenectomy

• Project/Area Number: 23591980
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Tsukuba
• Principal Investigator: WATANABE MOTONOBU 筑波大学, 医学医療系, 講師 (00568959)
• Co-Investigator(Kenkyū-buntansha): HISAKURA Katsuji 筑波大学, 医学医療系, 講師 (60550168)
• Co-Investigator(Renkei-kenkyūsha): OHKOHCHI Nobuhiro 筑波大学, 医学医療系, 教授 (40213673)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脾臓 / 肝細胞癌 / 免疫 / 発癌 / 癌発育 / 脾臓摘出 / 血小板

Research Abstract

The relationship between splenectomy and progression of HCC is still unclear. The purpose of this research is to evaluate the effect of splenectomy on progression of HCC and to develop a new therapy of HCC by splenectomy. One week after injecting murine HCC to wild type mouse liver through spleen, spleen ligation group mimicking splenectomy and control group were determined. Three weeks later, livers of both groups were removed. In the spleen ligation group, volume of HCC was significantly reduced compared to control group. This study suggests the suppressive effect of splenectomy on HCC progression.