Elucidation of the impact of chronic schistosomiasis japonica on recurrence and prognosis of the patients of hepatocellular carcinoma after hepatic resection and its mechanism.

• Project/Area Number: 23591983
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Yamanashi
• Principal Investigator: MATSUDA Masanori 山梨大学, 医学部附属病院, 講師 (80242642)
• Co-Investigator(Kenkyū-buntansha): AMEMIYA Hidetake 山梨大学, 医学部附属病院, 助教 (70377547)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 日本住血吸虫症 / 肝細胞癌 / 肝内胆管癌 / 肝切除 / 免疫障害 / 早期肝細胞癌 / 免疫抑制状態 / 腫瘍免疫 / 日本住血吸虫

Research Abstract

Proportion of hepatocellular carcinoma (HCC) patients with chronic schistosomiasis japonica (SJ) who underwent hepatic resection is about 18% in our department in recent years. Age in the SJ group was significantly higher and red blood cell count, IgM concentration and CD19 positive lymphocyte were significantly lower than in the non-SJ group. We assumed that deficiency in hematopoiesis and B cell function was adverse prognostic factor for survival after hepatic resection. Introduction of EOB-MRI and intraoperative contrast enhanced US and simultaneous treatment of early HCC prolonged survival after hepatic resection even in patients with chronic SJ.

Research Products

• [Journal Article] Pre operative gadoxetic acid-enhanced M RI and simultaneous treatment of ea rly hepatocellular carcinoma prolon ged recurrence-free survival of pro gressed hepatocellular carcinoma pa tients after hepatic resection (2014)
  • Author(s): Matsuda M, Ichikawa T, Amemiya H, M aki A, Watanabe M, Kawaida H, Kono H, Sano K, Motosugi U, Fujii H.
  • Journal Title: HPB surgery Volume: (1155/2014/641685)
  • Peer Reviewed
• [Journal Article] Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case. (2014)
  • Author(s): Matsuda M
  • Journal Title: Surg Today Volume: - Issue: 7 Pages: 1359-1366
  • DOI: 10.1007/s00595-013-0653-y
  • Peer Reviewed
• [Journal Article] Preoperative gadoxetic acid-enhanced MRI and simultaneous treatment of early hepatocellular carcinoma prolonged recurrence-free survival of progressed hepatocellular carcinoma patients after hepatic resection. (2014)
  • Author(s): Matsuda M
  • Journal Title: HPB surgery Volume: - Pages: 1-8
  • DOI: 10.1155/2014/641685
  • Peer Reviewed
• [Journal Article] Early hepatocellular carci nomas showing isointensity or hyper intensity in gadoxetic Acid-enhance d, hepatocyte-phase magnetic resona nce images (2013)
  • Author(s): Chen N, Motosugi U, Sano K, Ichikaw a T, Nakano M, Morisaka H, Ichikawa S, Matsuda M, Fujii H, Enomoto N, Araki T.
  • Journal Title: J Comput Assist Tomogr Volume: 37 Issue: 3 Pages: 466-469
  • DOI: 10.1097/rct.0b013e3182873799
  • Peer Reviewed
• [Journal Article] Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte-phase image is a risk factor for hypervascular hepatocellular carcinoma. (2013)
  • Author(s): Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T.
  • Journal Title: J Magn Reson Imaging. Volume: 39(2) Issue: 2 Pages: 293-297
  • DOI: 10.1002/jmri.24164
  • Peer Reviewed
• [Journal Article] Bayesian prediction for liver fibrosis staging: Combined use of elastography and serum fibrosis markers. (2013)
  • Author(s): Motosugi U
  • Journal Title: Hepatology Volume: 58 Issue: 1 Pages: 450-51
  • DOI: 10.1002/hep.26144
  • Peer Reviewed
• [Journal Article] Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case-control study. (2013)
  • Author(s): Motosugi U
  • Journal Title: Eur Radiol Volume: 23（1） Issue: 1 Pages: 156-62
  • DOI: 10.1007/s00330-012-2571-6
  • Peer Reviewed
• [Journal Article] Diffusion-weigh ted imaging of hepatocellular carci noma for predicting early recurrenc e and survival after hepatectomy (2013)
  • Author(s): Muhi A, Ichikawa T, Motosugi U, San o K, Fatima Z, Matsuda M, Fujii H, Enomoto N, Araki T.
  • Journal Title: Hepatol International Volume: 7 Issue: 2 Pages: 662-668
  • DOI: 10.1007/s12072-012-9383-2
  • Peer Reviewed
• [Journal Article] 最新の画像診断の進歩をベースにした肝細胞癌に対する新しい外科治療戦略の可能性：多発肝細胞癌の発生様式の診断と早期肝細胞癌の同時治療の意義 (2013)
  • Author(s): 松田政徳
  • Journal Title: 山梨医学 Volume: 41 Pages: 4-7
  • Peer Reviewed
• [Journal Article] Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C (2012)
  • Author(s): Ichikawa S, Motosugi U, Ichikawa T, Sano K, Morisaka H, Enomoto N, Mat suda M, Fujii H, Araki T.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 11 Issue: 4 Pages: 291-297
  • DOI: 10.2463/mrms.11.291
  • NAID: 10031145229
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Factors contri buting to the overall survival in p atients with hepatocellular carcino ma treated by sorafenib (2012)
  • Author(s): Tsukui Y, Mochizuki H, Hoshino Y, K awakami S, Kuno T, Fukasawa Y, Iwam oto F, Hirose S, Yoshida T, Hosoda K, Suzuki Y, Hosoda K, Kojima Y, Hi rose Y, Shindou K, Matsuda M, Yagaw a S, Tawara A, Kobayashi M, Konishi T, Yamazaki T, Takahashi S, Fuji H, Enomoto N, Omata M.
  • Journal Title: Hepatogast roenterology Volume: 59 Pages: 2536-2539
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=Factors+contributing+to+the+overall+survival+in+patients+with+hepatocellular+carcinoma+treated+by+sorafenib
  • Peer Reviewed
• [Journal Article] Magnetic resonance elastography for staging liver fibrosis in chronic hepatitis C. (2012)
  • Author(s): Ichikawa S
  • Journal Title: Magn Reson Med Sci Volume: 11 Pages: 291-297
  • Peer Reviewed
• [Journal Article] 肝切除における含水性伝達媒体(SonarAid®)を用いた術中超音波検査法の実際と有用性 (2012)
  • Author(s): 松田政徳
  • Journal Title: 山梨医学 Volume: 40 Pages: 65-69
  • Peer Reviewed
• [Journal Article] 早期肝細胞癌の画像診断 EOB-MRI 切除標本との対比 (2012)
  • Author(s): 佐野勝廣
  • Journal Title: 肝胆膵画像 Volume: 14 Pages: 319-323
• [Journal Article] 肝悪性腫瘍切除治療における術中超音波検査 (2012)
  • Author(s): 松田政徳
  • Journal Title: Innervision Volume: 28 Pages: 28-31
• [Journal Article] HCV-related proteins activate Kupff er cells isolated from human liver tissues (2011)
  • Author(s): Hosomura N, Kono H, Tsuchiya M, Ish ii K, Ogiku M, Matsuda M, Fujii H.
  • Journal Title: Dig Dis Sci. Volume: 56 Issue: 4 Pages: 1057-1064
  • DOI: 10.1007/s10620-010-1395-y
  • Peer Reviewed
• [Journal Article] Lens culinaris agglutinin-reactive fraction of AFP is a useful prognostic biomarker for survival after repeat hepatic resection for HCC (2011)
  • Author(s): Masanori Matsuda
  • Journal Title: J Gastroenterol Hepatol Volume: 26(4) Issue: 4 Pages: 731-738
  • DOI: 10.1111/j.1440-1746.2010.06532.x
  • Peer Reviewed
• [Journal Article] Double-dose gadoxetic Acid-enhanced magnetic resonance imaging in patients wi h chronicliver disease (2011)
  • Author(s): Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Kitamura T, Amemiya F, Enomoto N, Matsuda M, Asakawa M, Fujii H, Araki T.
  • Journal Title: Invest Radiol Volume: 46 Issue: 2 Pages: 141-145
  • DOI: 10.1097/rli.0b013e3181f9c487
  • Peer Reviewed
• [Journal Article] Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease (2011)
  • Author(s): Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Amemiya F, Enomoto N, Matsuda M, Fujii H, Araki T
  • Journal Title: J Magn Reson Imaging Volume: 34(1) Issue: 1 Pages: 88-94
  • DOI: 10.1002/jmri.22630
  • Peer Reviewed
• [Journal Article] Staging liver fibrosis by using liver-enhancement ratio of gadoxetic acid-enhanced MR imaging : comparison with aspartate aminotransferase-to-platelet ratio index (2011)
  • Author(s): Motosugi U, Ichikawa T, Oguri M, Sano K, Sou H, Muhi A, Matsuda M, Fuj ii H, Enomoto N, Araki T.
  • Journal Title: Magn Reson Imaging Volume: 29 Issue: 8 Pages: 1047-52
  • DOI: 10.1016/j.mri.2011.05.007
  • Peer Reviewed
• [Journal Article] Imaging study of early hepatocellular carcinoma : usefulness of gadoxetic acid-enhanced MR imaging (2011)
  • Author(s): Sano K, Ichikawa T, Motosugi U, Sou H, Muhi AM, Matsuda M, Nakano M, Sakamoto M, Nakazawa T, Asakawa M, F ujii H, Kitamura T, Enomoto N, Araki T.
  • Journal Title: Radiology Volume: 261 Issue: 3 Pages: 834-844
  • DOI: 10.1148/radiol.11101840
  • Peer Reviewed
• [Book] 我が国における非B非C肝硬変の実態調査 (2012)
  • Author(s): 松田政徳
  • Publisher: 響文社
• [Book] 腹部造影超音波フォーラム2011報告集 (2012)
  • Author(s): 松田政徳
  • Publisher: Innervision
• [Remarks]
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_Index.Main
• [Remarks] 山梨大学研究者総覧
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.List/3_70.html