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Elucidation of the impact of chronic schistosomiasis japonica on recurrence and prognosis of the patients of hepatocellular carcinoma after hepatic resection and its mechanism.

Research Project

Project/Area Number 23591983
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Yamanashi

Principal Investigator

MATSUDA Masanori  山梨大学, 医学部附属病院, 講師 (80242642)

Co-Investigator(Kenkyū-buntansha) AMEMIYA Hidetake  山梨大学, 医学部附属病院, 助教 (70377547)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords日本住血吸虫症 / 肝細胞癌 / 肝内胆管癌 / 肝切除 / 免疫障害 / 早期肝細胞癌 / 免疫抑制状態 / 腫瘍免疫 / 日本住血吸虫
Research Abstract

Proportion of hepatocellular carcinoma (HCC) patients with chronic schistosomiasis japonica (SJ) who underwent hepatic resection is about 18% in our department in recent years. Age in the SJ group was significantly higher and red blood cell count, IgM concentration and CD19 positive lymphocyte were significantly lower than in the non-SJ group. We assumed that deficiency in hematopoiesis and B cell function was adverse prognostic factor for survival after hepatic resection. Introduction of EOB-MRI and intraoperative contrast enhanced US and simultaneous treatment of early HCC prolonged survival after hepatic resection even in patients with chronic SJ.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 19 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Pre operative gadoxetic acid-enhanced M RI and simultaneous treatment of ea rly hepatocellular carcinoma prolon ged recurrence-free survival of pro gressed hepatocellular carcinoma pa tients after hepatic resection2014

    • Author(s)
      Matsuda M, Ichikawa T, Amemiya H, M aki A, Watanabe M, Kawaida H, Kono H, Sano K, Motosugi U, Fujii H.
    • Journal Title

      HPB surgery

      Volume: (1155/2014/641685)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case.2014

    • Author(s)
      Matsuda M
    • Journal Title

      Surg Today

      Volume: - Issue: 7 Pages: 1359-1366

    • DOI

      10.1007/s00595-013-0653-y

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative gadoxetic acid-enhanced MRI and simultaneous treatment of early hepatocellular carcinoma prolonged recurrence-free survival of progressed hepatocellular carcinoma patients after hepatic resection.2014

    • Author(s)
      Matsuda M
    • Journal Title

      HPB surgery

      Volume: - Pages: 1-8

    • DOI

      10.1155/2014/641685

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early hepatocellular carci nomas showing isointensity or hyper intensity in gadoxetic Acid-enhance d, hepatocyte-phase magnetic resona nce images2013

    • Author(s)
      Chen N, Motosugi U, Sano K, Ichikaw a T, Nakano M, Morisaka H, Ichikawa S, Matsuda M, Fujii H, Enomoto N, Araki T.
    • Journal Title

      J Comput Assist Tomogr

      Volume: 37 Issue: 3 Pages: 466-469

    • DOI

      10.1097/rct.0b013e3182873799

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte-phase image is a risk factor for hypervascular hepatocellular carcinoma.2013

    • Author(s)
      Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T.
    • Journal Title

      J Magn Reson Imaging.

      Volume: 39(2) Issue: 2 Pages: 293-297

    • DOI

      10.1002/jmri.24164

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bayesian prediction for liver fibrosis staging: Combined use of elastography and serum fibrosis markers.2013

    • Author(s)
      Motosugi U
    • Journal Title

      Hepatology

      Volume: 58 Issue: 1 Pages: 450-51

    • DOI

      10.1002/hep.26144

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case-control study.2013

    • Author(s)
      Motosugi U
    • Journal Title

      Eur Radiol

      Volume: 23(1) Issue: 1 Pages: 156-62

    • DOI

      10.1007/s00330-012-2571-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weigh ted imaging of hepatocellular carci noma for predicting early recurrenc e and survival after hepatectomy2013

    • Author(s)
      Muhi A, Ichikawa T, Motosugi U, San o K, Fatima Z, Matsuda M, Fujii H, Enomoto N, Araki T.
    • Journal Title

      Hepatol International

      Volume: 7 Issue: 2 Pages: 662-668

    • DOI

      10.1007/s12072-012-9383-2

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 最新の画像診断の進歩をベースにした肝細胞癌に対する新しい外科治療戦略の可能性:多発肝細胞癌の発生様式の診断と早期肝細胞癌の同時治療の意義2013

    • Author(s)
      松田政徳
    • Journal Title

      山梨医学

      Volume: 41 Pages: 4-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C2012

    • Author(s)
      Ichikawa S, Motosugi U, Ichikawa T, Sano K, Morisaka H, Enomoto N, Mat suda M, Fujii H, Araki T.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 11 Issue: 4 Pages: 291-297

    • DOI

      10.2463/mrms.11.291

    • NAID

      10031145229

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Factors contri buting to the overall survival in p atients with hepatocellular carcino ma treated by sorafenib2012

    • Author(s)
      Tsukui Y, Mochizuki H, Hoshino Y, K awakami S, Kuno T, Fukasawa Y, Iwam oto F, Hirose S, Yoshida T, Hosoda K, Suzuki Y, Hosoda K, Kojima Y, Hi rose Y, Shindou K, Matsuda M, Yagaw a S, Tawara A, Kobayashi M, Konishi T, Yamazaki T, Takahashi S, Fuji H, Enomoto N, Omata M.
    • Journal Title

      Hepatogast roenterology

      Volume: 59 Pages: 2536-2539

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=Factors+contributing+to+the+overall+survival+in+patients+with+hepatocellular+carcinoma+treated+by+sorafenib

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance elastography for staging liver fibrosis in chronic hepatitis C.2012

    • Author(s)
      Ichikawa S
    • Journal Title

      Magn Reson Med Sci

      Volume: 11 Pages: 291-297

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肝切除における含水性伝達媒体(SonarAid®)を用いた術中超音波検査法の実際と有用性2012

    • Author(s)
      松田政徳
    • Journal Title

      山梨医学

      Volume: 40 Pages: 65-69

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 早期肝細胞癌の画像診断 EOB-MRI 切除標本との対比2012

    • Author(s)
      佐野勝廣
    • Journal Title

      肝胆膵画像

      Volume: 14 Pages: 319-323

    • Related Report
      2012 Research-status Report
  • [Journal Article] 肝悪性腫瘍切除治療における術中超音波検査2012

    • Author(s)
      松田政徳
    • Journal Title

      Innervision

      Volume: 28 Pages: 28-31

    • Related Report
      2012 Research-status Report
  • [Journal Article] HCV-related proteins activate Kupff er cells isolated from human liver tissues2011

    • Author(s)
      Hosomura N, Kono H, Tsuchiya M, Ish ii K, Ogiku M, Matsuda M, Fujii H.
    • Journal Title

      Dig Dis Sci.

      Volume: 56 Issue: 4 Pages: 1057-1064

    • DOI

      10.1007/s10620-010-1395-y

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lens culinaris agglutinin-reactive fraction of AFP is a useful prognostic biomarker for survival after repeat hepatic resection for HCC2011

    • Author(s)
      Masanori Matsuda
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 26(4) Issue: 4 Pages: 731-738

    • DOI

      10.1111/j.1440-1746.2010.06532.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Double-dose gadoxetic Acid-enhanced magnetic resonance imaging in patients wi h chronicliver disease2011

    • Author(s)
      Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Kitamura T, Amemiya F, Enomoto N, Matsuda M, Asakawa M, Fujii H, Araki T.
    • Journal Title

      Invest Radiol

      Volume: 46 Issue: 2 Pages: 141-145

    • DOI

      10.1097/rli.0b013e3181f9c487

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease2011

    • Author(s)
      Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Amemiya F, Enomoto N, Matsuda M, Fujii H, Araki T
    • Journal Title

      J Magn Reson Imaging

      Volume: 34(1) Issue: 1 Pages: 88-94

    • DOI

      10.1002/jmri.22630

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Staging liver fibrosis by using liver-enhancement ratio of gadoxetic acid-enhanced MR imaging : comparison with aspartate aminotransferase-to-platelet ratio index2011

    • Author(s)
      Motosugi U, Ichikawa T, Oguri M, Sano K, Sou H, Muhi A, Matsuda M, Fuj ii H, Enomoto N, Araki T.
    • Journal Title

      Magn Reson Imaging

      Volume: 29 Issue: 8 Pages: 1047-52

    • DOI

      10.1016/j.mri.2011.05.007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging study of early hepatocellular carcinoma : usefulness of gadoxetic acid-enhanced MR imaging2011

    • Author(s)
      Sano K, Ichikawa T, Motosugi U, Sou H, Muhi AM, Matsuda M, Nakano M, Sakamoto M, Nakazawa T, Asakawa M, F ujii H, Kitamura T, Enomoto N, Araki T.
    • Journal Title

      Radiology

      Volume: 261 Issue: 3 Pages: 834-844

    • DOI

      10.1148/radiol.11101840

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Book] 我が国における非B非C肝硬変の実態調査2012

    • Author(s)
      松田政徳
    • Publisher
      響文社
    • Related Report
      2012 Research-status Report
  • [Book] 腹部造影超音波フォーラム2011報告集2012

    • Author(s)
      松田政徳
    • Publisher
      Innervision
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_Index.Main

    • Related Report
      2013 Final Research Report
  • [Remarks] 山梨大学研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.List/3_70.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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