Impact of autophagy in liver regeneration
| Project/Area Number |
23591989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIRABE Ken 九州大学, 医学研究院, 准教授 (70264025)
IKEGAMI Toru 九州大学, 医学研究院, 助教 (80432938)
YAMASHITA Yo-ichi 九州大学, 医学研究院, 助教 (00404070)
HARIMOTO Norifumi 九州大学, 医学研究院, 助教 (00419582)
UCHIYAMA Hideaki 九州大学, 医学研究院, その他 (70380425)
SOEJIMA Yuji 九州大学, 医学研究院, 共同研究員 (30325526)
NINOMIYA Mizuki 九州大学, 医学研究院, 助教 (30546461)
TAKETOMI Akinobu 九州大学, 医学研究院, 講師 (70363364)
MAEHARA Yoshihiko 九州大学, 医学研究院, 教授 (80165662)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝臓外科学 / オートファジー / 肝再生 |
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| Research Abstract |
We investigated the activity of autophagy-associated pathways in liver regeneration after partial hepatectomy (PHx) in liver-specific autophagy-related gene 5 (Atg5) knockout (KO) mice. Liver regeneration was severely impaired by 70% PHx, with a reduction in postoperative mitosis, but a compensating increase in hepatocyte size. PHx induced intracellular adenosine triphosphate and beta-oxidation reduction as well as injured cellular mitochondria. Furthermore, PHx in Atg5 KO mice enhanced hepatic accumulation of p62 and ubiquitinated proteins. These results indicated that reorganization of intracellular proteins and organelles during autophagy was impaired in the regenerating liver of these mice. Up-regulation of p21 was associated with hepatocyte senescence, senescence-associated b-galactosidase expression, irreversible growth arrest, and secretion of senescence-associated molecules, including interleukin (IL)-6 and IL-8.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Decreased immunoglobulin G levels after living-donor liver transplantation is a risk factor for bacterial infection and sepsis.2014
Author(s)
Yoshizumi T, Shirabe K, Ikegami T, Yamashita N, Mano Y, Yoshiya S, Matono R, Harimoto N, Uchiyama H, Toshima T, Maehara Y.
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Journal Title
Transpl Infect Dis.
Volume: 16
Issue: 2
Pages: 225-31
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of tumor size, number of tumors and neutrophil-to-lymphocyte ratio in liver transplantation for recurrent hepatocellular carcinoma.2013
Author(s)
Yoshizumi T, Ikegami T, Yoshiya S, Motomura T, Mano Y, Muto J, Ikeda T, Soejima Y, Shirabe K, Maehara Y.
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Journal Title
Hepatol Res.
Volume: 43
Issue: 7
Pages: 709-16
DOI
Related Report
Peer Reviewed
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[Presentation] 肝分化/再生/幹細胞肝再生におけるオートファジーの生物学的意義
Author(s)
戸島剛男, 調憲, 吉屋匠平, 武藤純, 的野る美, 間野洋平, 森田和豊, 萱島寛人, 池上徹, 吉住朋晴, 前原喜彦
Organizer
肝臓学会総会49回
Related Report
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[Presentation] 侵襲に対する生体反応とその制御肝再生におけるオートファジーの意義
Author(s)
戸島剛男, 調憲, 武冨紹信, 間野洋平, 武藤純, 的野る美, 吉屋匠平, 森田和豊, 萱島寛人, 池上徹, 吉住朋晴, 前原喜彦
Organizer
日本外科学会総会113回
Related Report
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[Presentation] 肝細胞癌進展におけるオートファジーの意義
Author(s)
戸島剛男, 調憲, 武冨紹信, 本村貴志, 間野洋平, 武藤純, 的野る美, 吉屋匠平, 森田和豊, 萱島寛人, 池上徹, 吉住朋晴, 前原喜彦
Organizer
日本癌治療学会総会51回
Related Report
