| Project/Area Number |
23591993
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Koichi 札幌医科大学, 医学部, 教授 (50136959)
MITAKA Toshihiro 札幌医科大学, 医学部, 教授 (50231618)
NAKAMURA Yukio 札幌医科大学, 医学部, 研究員 (50516648)
KAWAMOTO Masaki 札幌医科大学, 医学部, 助教 (70404605)
MEGURO Makoto 札幌医科大学, 医学部, 助教 (50448601)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝臓外科学 / 肝細胞移植 / 再生置換 / 肝機能 / 肝幹細胞 / 肝切除術 / 自己組織化 / 生体機能利用 / 移植 / 再生医療 / 応用動物 / アミノ酸 / 腹腔鏡 |
|---|
| Research Abstract |
We investigated that basic research for applying clinical liver regenerative therapy and clinical research for securing donor cell procurement. In the basic research, we developed a rat model of liver regenerative therapy by hepatocyte transplantation. In this model, we revealed a cell physiology of the transplanted cells which generated bile duct linage cells. In addition, we succeded to increase survival rate in NASH liver cirrhotic model. In the clinical research, we reported a benefit and default of donor cell procurement. We also revealed that a clinical value of BTR, ATIII, and GSA. We classified various liver functional indicators using clustering analysis. Furthermore, in technical reports, we developed a surgical devise for conducting safety right liver hepatectomy (J Am Col Surg : in press).
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