| Project/Area Number |
23592004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
SAKATA Jun 新潟大学, 医歯学総合病院, 講師 (70447605)
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| Co-Investigator(Kenkyū-buntansha) |
WAKAI Toshifumi 新潟大学, 医歯学系, 教授 (50372470)
白井 良夫 新潟大学, 医歯学系, 准教授 (50216173)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胆嚢癌 / リンパ節転移 / lymph node ratio / リンパ節転移個数 / 胆道外科学 |
|---|
| Research Abstract |
The aim of this study was to compare the anatomical location of positive nodes, number of positive nodes, and lymph node ratio (LNR) as prognostic predictors in gallbladder cancer. We conducted a retrospective analysis of 135 patients with gallbladder cancer who underwent a radical resection with regional lymphadenectomy.The location of positive nodes was classified according to the AJCC staging manual (7th edition).
Lymph node metastasis was found histologically in 59 (44%) patients. Univariate analysis identified location of positive nodes, number of positive nodes, and LNR as significant prognostic factors. Multivariate analysis identified number of positive nodes as an independent prognostic factor (P = 0.004); however, location of positive nodes and LNR failed to remain as an
independent variable.The number of positive lymph nodes better predicts patient outcome after resection than either the location of positive lymph nodes or LNR in patients with gallbladder cancer.
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