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The effect of prophylactic preoperative endoscopic transpapillary pancreatic stenting on clinically significant pancreatic fistula following distal pancreatectomy

Research Project

Project/Area Number 23592008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKobe University

Principal Investigator

MATSUMOTO Ippei  神戸大学, 医学部附属病院, 病院准教授 (30379408)

Co-Investigator(Kenkyū-buntansha) SHINZEKI Makoto  神戸大学, 医学部附属病院, 病院講師 (60444593)
TOYAMA Hirochika  神戸大学, 医学(系)研究科(研究院), 医学研究員 (10444598)
ASARI Sadaki  神戸大学, 医学部附属病院, 特定助教 (20580682)
GOTO Tadahiro  神戸大学, 医学部附属病院, 特定助教 (40580684)
HORI Yuichi  神戸大学, 保健学研究科, 教授 (80248004)
KU Yonson  神戸大学, 医学(系)研究科(研究院), 教授 (40195615)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords膵管ステント / 尾側膵切除術 / 術後膵液瘻 / 膵体尾部切除術 / 膵体尾部切叙述 / 膵液瘻 / 膵切除術
Research Abstract

Postoperative pancreatic fistula (PF) causes major morbidity after distal pancreatectomy (DP). The purpose of this prospective study is to determine whether prophylactic preoperative endoscopic transpapillary pancreatic stenting (EPS) reduces PF formation after DP. Fifteen patients underwent DP following EPS. Clinically significant PF (ISGPF [the International Study Group on Pancreatic Fistula] classification Grade B and C) occurred in 4 (26.7%). We decided to terminate the study after internal analysis because our study design required 35 patients with estimated PF rate 10%.
Prophylactic preoperative EPS dose not reduce PF after DP.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (11 results)

  • [Journal Article] A prospective randomized comparison between pylorus- and subtotal stomach-preserving pancreatoduodenectomy on postoperative delayed gastric emptying occurrence and long-term nutritional status.2014

    • Author(s)
      Matsumoto I, Shinzeki M, Asari S, Goto T, Shirakawa S, Ajiki T, Fukumoto T, Suzuki Y, Ku Y.
    • Journal Title

      J Surg Oncol.

      Volume: 109(7) Issue: 7 Pages: 690-696

    • DOI

      10.1002/jso.23566

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short- and Long-term Results of Extended Drainage Procedure for Chronic Pancreatitis : A Retrospective Japanese Single-Center Study2014

    • Author(s)
      Tanaka M, Matsumoto I, Shinzeki M, Asari S, Goto T, Yamashita H, Ishida J, Ajiki T, Fukumoto T, Ku Y.
    • Journal Title

      Kobe J Med Sci.

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of glucose metabolism after distal pancreatectomy according to the donor criteria of the living donor pancreas transplantation guidelines proposed by the Japanese Pancreas and Islet Transplantation Association2014

    • Author(s)
      Matsumoto I, Shinzeki M, Asari S, Goto T, Shirakawa S, Ajiki T, Fukumoto T, Ku Y.
    • Journal Title

      Transplant Proc.

      Volume: 46(3) Pages: 963-962

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short- and Long-term Results of Extended Drainage Procedure for Chronic Pancreatitis: A Retrospective Japanese Single-Center Study.2014

    • Author(s)
      Tanaka M, Matsumoto I, Shinzeki M, Asari S, Goto T, Yamashita H, Ishida J, Ajiki T, Fukumoto T, Ku Y
    • Journal Title

      Kobe J Med Sci.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of glucose metabolism after distal pancreatectomy according to the donor criteria of the living donor pancreas transplantation guideliEvaluation of glucose metabolism after distal pancreatectomy according to the donor criteria of the living donor pancreas transplantation guidelines proposed by the Japanese Pancreas and Islet Transplantation Association.2014

    • Author(s)
      Matsumoto I, Shinzeki M, Asari S, Goto T, Shirakawa S, Ajiki T, Fukumoto T, Ku Y
    • Journal Title

      Transplant Proc.

      Volume: 46(3) Issue: 3 Pages: 963-962

    • DOI

      10.1016/j.transproceed.2013.11.069

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An extremely rare portal annular pancreas for pancreaticoduodenectomy with a special note on the pancreatic duct management in the dorsal pancreas2013

    • Author(s)
      Matsumoto I, Shinzeki M, Fukumoto T, Ku Y.
    • Journal Title

      Surgery

      Volume: 153(3) Issue: 3 Pages: 434-436

    • DOI

      10.1016/j.surg.2011.08.017

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] MUC2 expression and prevalence of high-grade dysplasia and invasive carcinoma in mixed-type intraductal papillary mucinous neoplasm of the pancreas2013

    • Author(s)
      Masuda A, Matsumoto I, Ku Y, et al.
    • Journal Title

      Pancreatology

      Volume: 13 Issue: 6 Pages: 583

    • DOI

      10.1016/j.pan.2013.08.007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic volumetric assessment as a predictor of new-onset diabetes following distal pancreatectomy2012

    • Author(s)
      Shirakawa S, Matsumoto I, Toyama H, Shinzeki M, Ajiki T, Fukumoto T, Ku Y.
    • Journal Title

      J Gastrointest Surg

      Volume: 16(12) Issue: 12 Pages: 2212-2219

    • DOI

      10.1007/s11605-012-2039-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A focal mass-forming autoimmune pancreatitis mimicking pancreatic cancer with obstruction of the main pancreatic Duct2011

    • Author(s)
      Matsumoto I, Shinzeki M, Toyama H, Asari S, Goto T, Yamada I, Ajiki T, Fukumoto T, Ku Y.
    • Journal Title

      J Gastrointest Surg

      Volume: 15 Issue: 12 Pages: 2296-2298

    • DOI

      10.1007/s11605-011-1543-5

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 腹腔鏡下尾側膵切除術術式の定型化と技術認定医をめざして2013

    • Author(s)
      後藤直大
    • Organizer
      第26回日本内視鏡外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of the glucose metabolism after distal pancreatectomy according to the donor criteria of the living related donor pancreas transplantation guideline proposed by Japanese Pancreas and Islet Transplantation Association2013

    • Author(s)
      Matsumoto I.
    • Organizer
      The 13th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] 尾側膵切除後の新規糖尿病発症予測因子としての膵切除量の検討2013

    • Author(s)
      松本逸平
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Final Research Report
  • [Presentation] 腹腔鏡下尾側膵切除術-安全な術式の定型化-2012

    • Author(s)
      後藤直大
    • Organizer
      第74回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵腫瘍に対する腹腔鏡下尾側膵切除術2012

    • Author(s)
      新関亮
    • Organizer
      第43回日本膵臓学会
    • Place of Presentation
      山形
    • Related Report
      2013 Final Research Report
  • [Presentation] 主膵管近接腫瘍に対する膵腫瘍核出術の適応と手術手技の工夫2012

    • Author(s)
      松本逸平
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 腹腔鏡下膵切除術の適応と手術の実際2011

    • Author(s)
      松本逸平
    • Organizer
      第23回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 膵頭十二指腸切除術における膵液瘻のリスク因子解析2011

    • Author(s)
      新関 亮
    • Organizer
      第23回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 併存疾患を有する消化器癌の治療方針と術前・術後管理における注意点 外PD23-5:膵切除手術における肥満患者の術後膵液瘻リスク解析2011

    • Author(s)
      新関 亮
    • Organizer
      JDDW2011 第19回日本消化器関連学会週間
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 膵腫瘍核出術-主膵管近接例への工夫と手術手技-2011

    • Author(s)
      松本逸平
    • Organizer
      第73回日本臨床外科学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 腹腔鏡下膵切除術における適応と手技2011

    • Author(s)
      松本逸平
    • Organizer
      第24回日本内視鏡外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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