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Ischemia/Reperfusion-induced Myocardial Damage: Role of Carbon Dioxide

Research Project

Project/Area Number 23592023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionAkita University

Principal Investigator

YAMAMOTO Hiroshi  秋田大学, 医学(系)研究科(研究院), 准教授 (10270795)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Fumio  秋田大学, 大学院医学系研究科, 教授 (00127474)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords心筋虚血再灌流 / 二酸化炭素 / ナトリウム/水素交換 / ナトリウム/カルシウム交換 / 心筋保護 / 開心術 / 心筋虚血 / 虚血再灌流 / 塩素イオン / 重炭酸イオン / 心筋虚血再灌流傷害 / 好気的代謝 / 二酸化炭素産生 / イオン移動 / CO2産生
Research Abstract

We investigated the acid-base characteristic alterations of blood cardioplegia (BCP) during aortic cross-clamping in hearts arrested with BCP and during in vitro simulated ischemia. In 40 patients undergoing cardiac surgery following an aortic cross clamp, hearts were infused with a hypothermic BCP intermittently and lastly with a normothermic BCP prior to aortic cross clamp release. We measured pH, pCO2, [HCO3-], and [Cl-] of the coronary sinus effluent in the final BCP. BCP was assessed under in-vitro gassing at with 95% N2 + 5% CO2 (n = 6), 50% N2 + 50% CO2 (n = 3), or 100% CO2 (n = 6). The coronary sinus effluent, compared with the pre-infused BCP, exhibited significantly lower pH and greater pCO2 with no change in the [HCO3-] level. In vitro, the 100% CO2 gassing groups exhibited a significant increase in [HCO3-] under high pCO2-induced acidification. Under anoxia and CO2 retention during aortic cross-clamping, BCP can be a bicarbonate donor to the myocardium.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Rupture of chronic type B aortic dissection in a Jehovah's Witness: successful surgical repair without blood transfusion.2012

    • Author(s)
      Yamamoto H, Yamamoto F, Yamaura G, Motokawa M, Tanaka F, Sato H, Ishibashi K, Shiroto K.
    • Journal Title

      Ann Vasc Surg

      Volume: 26 Issue: 4 Pages: 571.e11-571.e16

    • DOI

      10.1016/j.avsg.2011.08.019

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two cases of calcified amorphous tumor mimicking mitral valve vegetation.2012

    • Author(s)
      Fujiwara M, Watanabe H, Iino T, Kobukai Y, Ishibashi K, Yamamoto H, Iino K, Yamamoto F, Ito H.
    • Journal Title

      Circulation

      Volume: 13 Issue: 10

    • DOI

      10.1161/circulationaha.111.072793

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Right atrial giant myxoma occupying the right ventricular cavity.2012

    • Author(s)
      Sato T, Watanabe H, Okawa M, Iino T, Iino K, Ishibashi K, Yamamoto H, Yamamoto F, Ito H.
    • Journal Title

      Ann Thorac Surg

      Volume: 94 Issue: 2 Pages: 643-646

    • DOI

      10.1016/j.athoracsur.2011.12.084

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A free-floating left atrial thrombus develops intermittent entrapment in the mid-ventricle during diastole.2012

    • Author(s)
      4) Fujiwara M, Watanabe H, Oguma Y, Yamaura G, Ishibashi K, Yamamoto H, Nobori K, Yamamoto F, Ito H.
    • Journal Title

      Heart Vessels

      Volume: 27 Pages: 428-431

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of L-type Ca2+ current in left atrial myocytes of rats during experimental cardiac hypertrophy.2012

    • Author(s)
      5) Zhang C, Okamoto Y, Ohba T, Ishibashi K, Yamamoto H, Ono K, Yamamoto F.
    • Journal Title

      Akita J Med

      Volume: 39 Pages: 61-71

    • NAID

      110009575393

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blood Cardioplegia Serves as a Bicarbonate Donor to the Myocardium during Ischemia : Effects of Anoxia and Hypercapnia on Acid-Base Characteristics of Blood Cardioplegic Solution2011

    • Author(s)
      Hiroshi Yamamoto, Kazutomo Goh, Katsuaki Magishi, Tadahiro Sasajima, Fumio Yamamoto
    • Journal Title

      Eur Surg Res.

      Volume: 47

    • Related Report
      2013 Final Research Report
  • [Journal Article] Blood cardioplegia serves as a bicarbonate donor to the myocardium during ischemia: effects of anoxia and hypercapnia on acid-base characteristics of blood cardioplegic solution.2011

    • Author(s)
      Hiroshi Yamamoto, Kazutomo Goh, Katsuaki Magishi, Tadahiro Sasajima, Fumio Yamamoto.
    • Journal Title

      European Surgical Research

      Volume: 47 Pages: 267-273

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 破裂性感染性大動脈瘤に対する異種心膜ロールを用いた血行再建2012

    • Author(s)
      山本浩史, 山本文雄, 石橋和幸, 山浦玄武, 佐藤央, 白戸圭介, 本川真美加, 田中郁信, 張春鵬
    • Organizer
      第42回日本心臓血管外科学会学術総会
    • Place of Presentation
      秋田
    • Related Report
      2012 Research-status Report
  • [Presentation] 高齢者における破裂性腹部大動脈瘤手術の遠隔予後:長期生命予後とQOLの向上にむけて2012

    • Author(s)
      山本浩史, 山本文雄, 石橋和幸, 山浦玄武, 佐藤央, 白戸圭介, 本川真美加, 田中郁信, 張春鵬
    • Organizer
      第40回日本血管外科学会学術総会
    • Place of Presentation
      長野
    • Related Report
      2012 Research-status Report
  • [Presentation] Stanford B型急性大動脈解離のストラテジー:解離関連合併症の有無と遠隔治療成績2012

    • Author(s)
      山本浩史, 山本文雄, 石橋和幸, 山浦玄武, 佐藤央, 白戸圭介, 本川真美加, 田中郁信, 張春鵬
    • Organizer
      第65回日本胸部外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 術後遠隔成績・QOLから考える80歳以上の緊急大動脈手術の妥当性2012

    • Author(s)
      山本浩史、山本文雄、石橋和幸、山浦玄武、佐藤 央、白戸圭介、本川真美加、田中郁信、張 春鵬
    • Organizer
      第43回日本心臓血管外科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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