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The prevention of perioperative mortal arrhythmia : the effect of Granulocyte-Colony Stimulating Factor Administration

Research Project

Project/Area Number 23592025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIMOJO Nobutake  筑波大学, 医学医療系, 講師 (20462210)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心臓大血管外科学 / 致死性不整脈 / 顆粒球コローニー刺激因子 / 集中治療学 / 致死性不整 / up-stream治療 / G-CSF
Research Abstract

The antiarrhythmic effect of Granulocyte colony-stimulating factor (G-CSF) on hypertrophic cardiomyopathy (HCM) has not been clarified. Salt-sensitive rats were maintained on a high-salt diet as HCM models (n=17) and a low-salt as normal heart models (NH; n=5). After the treatments with 50microg/kg (i.p.) of G-CSF (9 HCMs and 2 NHs) and vehicle (8 HCMs and 3 NHs), rapid ventricular pacing was performed to evaluate the vulnerability to VT. The G-CSF reduced inducibility of VT as compared to vehicle in HCM (1 of 9 vs. 5 of 8, p=0.03). In addition, VT was not inducible in NH treated with G-CSF, although it was inducible in 1 of 3 NHs treated with vehicle. The G-CSF increased the phosphorylated Connexin-43 level as compared to vehicle in both HCM (1.4-fold vs. 1.2-fold, p<0.01) and NH (1.4-fold vs. 1-fold, p=0.04). The G-CSF is proposed as an antiarrhythmic agent in patients with HCM, because it reduces the vulnerability to VT by up-regulating the phosphorylated Connexin-43.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (9 results)

  • [Journal Article] Fish oil constituent eicosapentaenoic acid inhibits endothelin-induced cardiomyocyte hypertrophy via PPAR-α2014

    • Author(s)
      Shimojo N, Jesmin S, Sakai S, Maeda S, Miyauchi T, Mizutani T, Aonuma K, Kawano S
    • Journal Title

      Life Sci

      Volume: (in press) Issue: 2 Pages: 445-7

    • DOI

      10.1016/j.lfs.2014.04.025

    • NAID

      120007130480

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy.2014

    • Author(s)
      Sakai S, Shimojo N, Kimura T, Tajiri K, Maruyama H, Homma S, Kuga K, Mizutani T, Aonuma K, Miyauchi T.
    • Journal Title

      Life Sci.

      Volume: 102 Issue: 2 Pages: 98-104

    • DOI

      10.1016/j.lfs.2014.03.018

    • NAID

      120007136696

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant reversal of cardiac upregulated endothelin-1 system in a rat model of sepsis by landiolol hydrochloride2014

    • Author(s)
      Yoshimoto Seki, Subrina Jesmin, Nobutake Shimojo, Majedul Islam, Arifur Rahman, Tanzila Khatun, Hidekazu Sakuramoto, Masami Oki, Aiko Sonobe, Junko Kamiyama, Keiichi Hagiya, Satoru Kawano, Taro Mizutani
    • Journal Title

      Life Sci.

      Volume: S0024-3205(14) Pages: 405-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model2014

    • Author(s)
      Masami Oki, Subrina Jesmin, Majedul Islam, Chinba N Mowa, Tanzila Khatun, Nobutake Shimojo, Hideaki Sakuramoto, Junko Kamiyama, Satoru Kawano, Takashi Miyauchi, Taro Mizutani
    • Journal Title

      Life Sci.

      Volume: S0024-3205(14) Pages: 238-0

    • NAID

      120007130485

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice2013

    • Author(s)
      Kazuko Tajiri, Nobutake Shimojo, satoshi Sakai, Tomoko Machino-Ohtsuka, Kyoko Imanaka-Yoshida, Michiaki Hiroe, Yoshiko Tsujimura, Taizo Kimura, Akira Sato, Yasuhiro Yasutomi, Kazutaka Aonuma
    • Journal Title

      Cardiovasc Drugs Ther

      Volume: 27(5) Issue: 5 Pages: 413-24

    • DOI

      10.1007/s10557-013-6464-y

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Effects of landiolol hydrochloride, an ultra-short-actingβ-blocker, on cardiac endothelin system in a rat model of endotoxemia : a possible relevance with cardiac functional compensatory events at the early phase of sepsis2013

    • Author(s)
      Yoshimoto Seki, Nobutake Shimojo, Jesmin Subrina, Majedul Islam, Tanzila Khatun, Hideaki Sakuramoto, Junko Kamiyama, Keiichi Hagiya, Satoru Kawano, Taro Mizutani
    • Organizer
      International Conference on Endothelin
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibitory effect of Eicosapentaenoic acid on cardiomyocyte in endothelin induced hypertrophy via PPAR-α2013

    • Author(s)
      Nobutake Shimojo, Subrina Jesmin, Satoshi Sakai, Seiji Maeda, Takashi Miyauchi, Satoru Kawano, Taro Mizutani, Kazutaka Aonuma
    • Organizer
      International Conference on Endothelin
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2013-09-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Dual endothelin blockade exacerbates upregulated VEGF angiogenic signaling in the heart of lipopolysaccharide -induced endotoxemic rat model2013

    • Author(s)
      Masami Oki, Subrina Jesmin, Nobutake Shimojo, Majedul Islam, Tanzila Khatun, Hideaki Sakuramoto, Junko Kamiyama, Satoru Kawano, Taro Mizutani
    • Organizer
      International Conference on Endothelin
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Pitavastatin ameliorates experimental autoimmune myocarditis by decreased Th1/Th17 cytokines in mice2012

    • Author(s)
      Kazuko Tajiri, Nobutake Shimojo, Kazutaka Aonuma
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2012-08-25
    • Related Report
      2013 Final Research Report
  • [Presentation] G-CSF Reduces Inducibility of Ventricular Tachycardia via Up-regulation of Phosphorylated Connexin-43 in Left Ventricular Hypertrophy Model Rats2011

    • Author(s)
      Takeshi Machino, Nobutake Shimojo, Dongzhu Xu, Rumi Koshitsuka, Yuri Kameda, Hideaki Sakuramoto, Satoru Kawano, Yukio Sekiguchi, Hiroshi Tada, and Kazutaka Aonuma
    • Organizer
      日本循環器学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] G-CSF Reduces Ventricular Tachycardia Inducibility in the Cardiac Hypertrophy via Up-regulation of Phosphorylated Connexin-432011

    • Author(s)
      Takeshi Machino, Nobutake Shimojo, Dongzhu Xu, Hiro Yamasaki, Miyako Igarashi, Kentaro Yoshida, Yukio Sekiguchi, Hiroshi Tada, and Kazutaka Aonuma
    • Organizer
      Heart Rhythm 2011
    • Place of Presentation
      San Francisco, California
    • Year and Date
      2011-05-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Granulocyte colony-stimulating factor administration reduced the inducibility of ventricular tachyarrhythmias in cardiac hypertrophied rats through phosphorylated connexin-43.2011

    • Author(s)
      Nobutake Shimojo, Takeshi Machino, Donzhu Xu, Taizo Kimura, Rumi Koshizuka, Yuri Kameda, Satoshi Sakai, Kazutaka Aonuma
    • Organizer
      Basic Cardiovascular Science2011 Scientific Sessions
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] G-CSF Reduces Ventricular Tachycardia Inducibility in the Cardiac Hypertrophy via Upregulation of Phosphorylated Connexin-43.

    • Author(s)
      Takeshi Machino, Nobutake Shimojo, Donzhu Xu, Hiro Yamasaki, Miyako Igarashi, Yukio Sekiguchi, Hiroshi Tada, Kazutaka Aonuma.
    • Organizer
      Heart Rhythm society’s 32th Annual Scientific sessions
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2012 Research-status Report 2011 Research-status Report
  • [Presentation] G-CSF Reduces Inducibility of Ventricular Tachycardia via Up-regulation of Phosphorylated Connexin-43 in Left Ventricular Hypertrophy Model Rats.

    • Author(s)
      Takeshi Machino, Nobutake Shimojo, Dongzhu Xu, Rumi Koshitsuka, Yuri Kameda, Hideaki Sakuramoto, Satoru Kawano, Yukio Sekiguchi, Hiroshi Tada, and Kazutaka Aonuma
    • Organizer
      日本循環器学会学術集会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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