• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The Cardioprotective Effect Of Interleukin-11 in Cardiac Surgery

Research Project

Project/Area Number 23592027
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

KOUNO Hiroki  千葉大学, 医学部附属病院, 助教 (40375803)

Co-Investigator(Kenkyū-buntansha) MATSUMIYA Goro  千葉大学, 大学院医学研究院, 教授 (20314312)
ISHIZAKA Toru  千葉大学, 医学部附属病院, 講師 (10372616)
ISHIDA Keiichi  千葉大学, 医学部附属病院, 助教 (40375671)
FUJIO Yasushi  大阪大学, 薬学研究科, 教授 (20359839)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsIL-11 / 心臓血管外科 / 心筋保護効果
Research Abstract

<Objective> We sought to evaluate the cardioprotective effect of IL-11 during prolonged hypothermic ischemia and subsequent reperfusion using a rat heart donor model. <Methods> IL-11 was administered intravenously before harvesting the rat heart. The hearts were preserved in cold buffer for 6 hours, and then mounted onto a Langendorff perfusion apparatus for reperfusion using an oxygenated solution containing IL-11. Normal saline was used instead of IL-11 in the control group. Functional recovery of the reperfused heart was observed and measured, and apoptotic cells were counted using the TUNEL staining technique. <Results> Functional recovery was significant after 6 hours of cold ischemia in the IL-11 group. The number of apoptotic cells was also significantly smaller in the IL-11 group. <Conclusion> IL-11 significantly protected the heart in this rat ischemic model. This was associated with the prevention of apoptosis of the cells exposed to the ischemia-reperfusion injury.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi