Phosphate binders inhibit calcification of aortic and cardiac valve allografts.
| Project/Area Number |
23592028
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ONO Minoru 東京大学, 医学部附属病院, 教授 (40270871)
MOTOMURA Noboru 東京大学, 医学部附属病院, 准教授 (40332580)
SAITO Aya 東京大学, 医学部附属病院, 講師 (10431868)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 同種心臓弁・血管移植 / 石灰化 / リン酸バインダー |
|---|
| Research Abstract |
<OBJECTIVES> We hypothesized that phosphate binders, lanthanum carbonate (LC) and calcium carbonate (CC), inhibit calcification of implanted aortic allografts (AAs) in young recipients, and verified this hypothesis. <METHODS> Aorta was harvested from BN rat and implanted into subcutaneous space of LEW rat. Recipient rats were divided into group-N (g-N), group-L (g-L), and group-C (g-C). G-N was fed by normal diets (ND), g-L by ND plus LC, g-C by ND plus CC. The implanted AAs were explanted 2 weeks after implantation and serum sample was taken at sacrifice. <RESULTS> Calcification was significantly inhibited in g-L and g-C than in g-N, qualitatively and quantitatively. Serum Ca of g-C was significantly higher than that of g-N and g-L. Both LC and CC reduced serum Pi significantly. <CONCLUSIONS> Phosphate binders, LC and CC, inhibit calcification of implanted AAs in young rat subdermal implantation model. CC induced significant hypercalcemia and LC has a more potential for clinical use.
|
Report
(4 results)
Research Products
(26 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 東京大学医学部附属病院組織バンク部ドナー情報対応地域拡大後の現状と展望2013
Author(s)
三瓶 祐次, 関 美智子, 服部 理, 田村 純人, 齋藤 綾, 木下 修, 尾崎 晋一, 山内 治雄, 菅原 寧彦, 小野 稔, 國土 典宏, 本村 昇
Organizer
日本組織移植学会総会・学術集会
Place of Presentation
さいたま市
Related Report
-
[Presentation] 東京大学医学部附属病院組織バンク部の業務における最近の工夫2013
Author(s)
関 美智子, 服部 理, 三瓶 祐次, 田村 純人, 齋藤 綾, 木下 修, 尾崎 晋一, 山内 治雄, 菅原 寧彦, 小野 稔, 國土 典宏, 本村 昇
Organizer
日本組織移植学会総会・学術集会
Place of Presentation
さいたま市
Related Report
-
-
-
-
-
-
-
-
[Presentation] 東京大学医学部附属病院組織バンク、ドナー情報対応休止から再開に至るまでの活動状況2011
Author(s)
服部理, 織田乃梨子, 田村純人, 齋藤綾, 関美智子, 木下修, 嶋田正吾, 菅原寧彦, 小野稔, 國土典宏, 本村昇
Organizer
第10回日本組織移植学会学術集会
Place of Presentation
東京
Year and Date
2011-08-06
Related Report
-
[Presentation] 東京大学医学部附属病院組織バンク2004-2010年におけるシッピング活動状況2011
Author(s)
織田乃梨子, 服部理, 田村純人, 齋藤綾, 関美智子, 木下修, 嶋田正吾, 菅原寧彦, 小野稔, 國土典宏, 本村昇
Organizer
第10回日本組織移植学会学術集会
Place of Presentation
東京
Year and Date
2011-08-06
Related Report
-
