| Project/Area Number |
23592028
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ONO Minoru 東京大学, 医学部附属病院, 教授 (40270871)
MOTOMURA Noboru 東京大学, 医学部附属病院, 准教授 (40332580)
SAITO Aya 東京大学, 医学部附属病院, 講師 (10431868)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 同種心臓弁・血管移植 / 石灰化 / リン酸バインダー |
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| Research Abstract |
<OBJECTIVES> We hypothesized that phosphate binders, lanthanum carbonate (LC) and calcium carbonate (CC), inhibit calcification of implanted aortic allografts (AAs) in young recipients, and verified this hypothesis. <METHODS> Aorta was harvested from BN rat and implanted into subcutaneous space of LEW rat. Recipient rats were divided into group-N (g-N), group-L (g-L), and group-C (g-C). G-N was fed by normal diets (ND), g-L by ND plus LC, g-C by ND plus CC. The implanted AAs were explanted 2 weeks after implantation and serum sample was taken at sacrifice. <RESULTS> Calcification was significantly inhibited in g-L and g-C than in g-N, qualitatively and quantitatively. Serum Ca of g-C was significantly higher than that of g-N and g-L. Both LC and CC reduced serum Pi significantly. <CONCLUSIONS> Phosphate binders, LC and CC, inhibit calcification of implanted AAs in young rat subdermal implantation model. CC induced significant hypercalcemia and LC has a more potential for clinical use.
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