Study of myocardial protection by sympathetic nerve stimulation using a new SPY-Q system myocardial blood flow evaluation

Research Project

Project/Area Number	23592031
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Thoracic surgery
Research Institution	Kanazawa University
Principal Investigator	TOMITA Shigeyuki 金沢大学, 大学病院, 助教 (90334771)
Co-Investigator(Kenkyū-buntansha)	WATANABE Go 金沢大学, 医学系, 教授 (60242492)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000) Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords	交感神経刺激 / 高周波刺激 / 心筋酸素代謝 / 心筋保護法 / Ganglion Plexus / 副交感神経刺激 / 心筋血流 / 電気的心筋保護法 / 神経刺激心停止 / 心筋酸素飽和度
Research Abstract	The purpose of this study is to obtain safety cardiac arrest by sustained stimulation of bilateral sympathetic nerve and Ganglion Plexus. Using a pen type bipolar stimulation device (25-30 Hz, rectangular bipolar pulse, output 8 V, pulse width 0.4 ms) with distance between electrodes 3 mm, a stable cardiac arrest was obtained during 30 minutes. During stimulation (30 minutes), cardiac arrest was obtained and after stopping stimulation, heart beating was started immediately. Heart rate and systemic blood pressure were recovered to the controlled value in about 10 minutes. During cardiac arrest, myocardial blood flow and myocardial oxygen saturation were not decreased. The new cardiac protection of the sympathetic nerve stimulation resulted in safe and useful methods without decreasing of cardiac dysfunction and myocardial oxygen metabolism.