Development of Novel Immuno-tolerance Treatment of Cardiac Transplantation by Cardiac Progenitor Cells from Explanted Heart
| Project/Area Number |
23592036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
ARAI Sadahiko 岡山大学, 医歯(薬)学総合研究科, 助教 (50345617)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 冠動脈外科 / 心臓血管外科 / 幹細胞治療 / 再生医療 / 心移植 / 先天性心疾患 / 心筋幹細胞 / 拒絶反応抑制 |
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| Research Abstract |
We purified cardiac progenitor cell from congenital heart disease patients and established iPS cells. We transplanted these cells into rat decellularized extracellular matrix by transcoronary injection. We observed neo genesis of cardiovascular tissue in peri-coronary area. This result showed possible application of regeneration therapy to bio artificial heart or transplantation. We examined gene expression of iPS cells from hypoplastic left heart syndrome patients. We observed suppression of specific basic transcription factors and increased expression of other gene group. Those gene are potentially considered to be related to expression of congenital anomaly.
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Report
(4 results)
Research Products
(4 results)
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[Presentation] 疾患特異的iPS細胞を用いた左心低形成症候群における心臓発生異常の解明(優秀演題口演)2013
Author(s)
小林純子,樽井俊,平田昌敬,川畑拓也,黒子洋介,立石篤史,吉積功,新井禎彦,笠原真悟,佐野俊二,王英正
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡
Year and Date
2013-04-12
Related Report
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