Preoperative simulation of pediatric cardiac surgery analyzed by computational fluid dynamic study

• Project/Area Number: 23592041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Ehime University
• Principal Investigator: SHIKATA Fumiaki 愛媛大学, 医学部附属病院, 助教 (90457359)
• Co-Investigator(Kenkyū-buntansha): NAGASHIMA Mitsugi 東京女子医科大学, 医学部, 准教授 (90256610) ; OKAMURA Toru 愛媛大学, 医学部附属病院, 講師(病院教員) (20277198) ; HIGAKI Takashi 愛媛大学, 医学部附属病院, 准教授 (60253308) ; OKURA Masahiro 愛媛大学, 医学部附属病院, 助教 (10408601)
• Co-Investigator(Renkei-kenkyūsha): UMEDU Mitsuo 早稲田大学, 理工学術院, 教授 (90132927)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 流体シミレーション / 先天性心疾患 / フォンタン手術 / グレン手術 / 小児心臓手術 / 術前シミュレーション / CFD / CAD / 流体力学 / 数値流体力学 / 小児心臓血管外科 / 機能的単心室

Research Abstract

Early survival after Fontan procedure has improved dramatically for the development of perioperative surgical treatment and strategy based on each surgeon's experience and scientific data. Despite of these improvement, there are still concerns about long-term complications, i.e. pulmonary arteriovenous malformation and thrombus formation in the conduit, which can less the quality of life after surgery. We simulated the optimal design of procedures with computational fluid dynamics to gain the better quality of survival and the optimal anastomosis was developed both in Fontan and Glenn procedure. This technique could be applied to designing of the different type of pediatric cardiac surgery, which is expected to lead the better quality of life after surgery.

Research Products

• [Journal Article] Pathophysiology of lung injury induced by common bile duct ligation in mice (2014)
  • Author(s): Shikata F, Sakaue T, Nakashiro K, Okazaki M, Kurata M, Okamura T, Okura M, Ryugo M, Nakamura Y, Yasugi T, Higashiyama S, Izutani H.
  • Journal Title: PLoS ONE Volume: 9
  • Peer Reviewed
• [Journal Article] Pathophysiology of lung injury induced by common bile duct ligation in mice. (2014)
  • Author(s): Shikata, F., Sakaue, T., Nakashiro, K., Okazaki, M., Kurata, M., Okamura, T., Okura, M., Ryugo, M., Nakamura, Y., Yasugi, T., Higashiyama, S., Izutani, H.
  • Journal Title: PLoS ONE Volume: 9
  • Peer Reviewed
• [Presentation] Lung injury induced by common bile duct ligation in mice (2014)
  • Author(s): Shikata F, Sakaue T, Nakashiro K, Okazaki M, Kurata M, Okamura T, Okura M, Ryugo M, Nakamura Y, Yasugi T, Higashiyama S, Izutani H.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
• [Presentation] Lung injury induced by common bile duct ligation in mice. (2014)
  • Author(s): Shikata, F., Sakaue, T., Nakashiro, K., Okazaki, M., Kurata, M., Okamura, T., Okura, M., Ryugo, M., Nakamura, Y., Yasugi, T., Higashiyama, S., Izutani, H.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
• [Presentation] 両側上大静脈例での心外導管型Fontan手術における血流シミュレーションを用いた下大静脈血流分配の検討 (2013)
  • Author(s): 大倉正寛, 岡村達, 鹿田文昭, 泉谷裕則, 板谷慶一, 宮地鑑, 宮崎翔平, 梅津光生
  • Organizer: 第33回日本小児循環動態研究会学術集会
  • Place of Presentation: 愛知県女性総合センターウィルあいち:名古屋
• [Presentation] 両側上大静脈例での心外導管型Fontan手術における血流シミュレーションを用いた下大静脈血流分配の検討 (2013)
  • Author(s): 大倉正寛 岡村達 鹿田文昭 泉谷裕則 板谷慶一 宮地 鑑 宮崎翔平 梅津光生
  • Organizer: 第３３回 日本小児循環動態研究会学術集会
  • Place of Presentation: 愛知県女性総合センターウィルあいち：名古屋
• [Presentation] Influence of anastomosis angle between the graft and the pulmonary artery on the flow dynamics in the total cavopulmonary connection (2012)
  • Author(s): Nagashima M, Shikata F, Okamura T, Itatani K, Miyakoshi T, Liu J, Yi Q, Umezu M, Miyaji K.
  • Organizer: The Society of Thoracic Surgeon 48th Annual Meeting
  • Place of Presentation: 米国フロリダ
• [Presentation] Influence of Anastomosis Angle Between the Graft and the Pulmonary Artery on the Flow Dynamics in the Total Cavopulmonary Connection (2012)
  • Author(s): M. Nagashima, F. Shikata, T. Okamura, K. Itatani, T. Miyakoshi, J. Liu, Q. Yi, M. Umezu, K. Miyaji
  • Organizer: The Society of Thoracic Surgeon 48th Annual Meeting
  • Place of Presentation: 米国 フロリダ州 フォートローダーデール
• [Presentation] A computational fluid dynamic study of extracardiac total cavopulmonary connection using imaging data acquired by multi-detector computed tomography (2011)
  • Author(s): Shikata F, Nagashima M, Itatani K, Okamura T, Higaki T, Kurata A, Mochizuki T, Yamamoto E, Ohta M, Takata H, Chisaka T, Qian Y, Umezu M.
  • Organizer: 6th Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography
  • Place of Presentation: 米国コロラド
• [Presentation] A computational fluid dynamic study of extracardiac total cavopulmonary connection using imaging data acquired by multi-detector computed tomography (2011)
  • Author(s): Shikata F, Nagashima M, Itatani K, Okamura T, Higaki T, Kurata A, Mochizuki T, Yamamoto E, Ohta M, Takata H, Chisaka T, Qian Y, Umezu M
  • Organizer: 6th Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography
  • Place of Presentation: 米国 コロラド州 デンバー