Endoplasmic reticulum stress response in motor neuron after transient ischemia in rabbits

• Project/Area Number: 23592043
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kyushu University
• Principal Investigator: NAKASHIMA ATSUHIRO 九州大学, 大学病院, 助教 (10260704)
• Co-Investigator(Kenkyū-buntansha): SHIOKAWA Yuichi 九州大学, 医学部, 准教授 (70457422) ; OISHI Yasuhisa 九州大学, 病院, 助教 (20529870)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脊髄虚血 / 小胞体ストレス / オートファジー

Research Abstract

The purpose of the present study was to investigate the role of endoplasmic reticulum stress response in motor neuron death after transient ischemia in rabbits. However it was not possible to extract the edoplasmnic reticulum stress relation protein enough for the analysis. Therefore, we investigated the role of autophagy-mediated stress response. We recognized that the prolonged induction of autophagy might be a potential factor responsible for delayed motor neuron death, and the induction of the autophagy inhibitory protein Bcl-2.