| Project/Area Number |
23592051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SAITO Tomohiro 独立行政法人国立循環器病研究センター, 研究所, 派遣研究員 (20598221)
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| Co-Investigator(Kenkyū-buntansha) |
TODA Koichi 大阪大学, 医学(系)研究科(研究院), 准教授 (40379235)
MISUMI Yusuke 国立循環器病研究センター, 病院, レジデント (20631477)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUKIYA Tomonori 国立循環器病研究センター, 研究所, 室長 (00311449)
OHNUMA Kentaro 国立循環器病研究センター, 研究所, 流動研究員 (50527992)
HANADA Shigeru 国立循環器病研究センター, 研究所, 派遣研究員 (90514547)
KATAGIRI Nobumasa 国立循環器病研究センター, 研究所, 特任研究員 (00463274)
SUMIKURA Hirohito 国立循環器病研究センター, 研究所, 流動研究員 (20433998)
MIZUNO Toshihide 国立循環器病研究センター, 研究所, 室長 (40426515)
TAKEWA Yoshiaki 国立循環器病研究センター, 研究所, 室長 (20332405)
TATSUMI Eisuke 国立循環器病研究センター, 研究所, 部長 (00216996)
TAENAKA Yoshiyuki 国立循環器病研究センター, 研究所, 副所長 (00142183)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 左心補助人工心臓 / 右心不全 / 低侵襲治療 / 急性動物実験 / 補助人工心臓 / 心不全動物 / 非侵襲的治療 / 心房内シャントによる右心不全の改善 |
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| Outline of Final Research Achievements |
Right ventricular dysfunction after implantation of left ventricular assist device (LVAD) leads high mortality. This study was conducted in acute animal experiments to develop a new methods to improve the outcome of the patients with LVAD complicated with right ventricular dysfunction. We assessed the balloon atrial septostomy (BAS) as an alternative treatment for the right ventricular dysfunction. Seven goats supported with LVAD were introduced right ventricular dysfunction and BAS was performed. BAS was safely underwent under the support of LVAD. LAVD flow was increased and the hemodynamics of the goats were significantly improved after the procedure. This results were presented at the Souther thoracic surgical association 59th annual meeting 2012 in Florida and the 52th annual meeting of the Japanese society for artificial organs 2014 in Sapporo, and published as original article after peer review by European journal of cardiothoracic surgery.
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