| Project/Area Number |
23592053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野口 雅之 筑波大学, 医学医療系, 教授 (00198582)
佐藤 幸夫 筑波大学, 医学医療系, 教授 (10312844)
松下 昌之助 筑波技術大学, 保健科学部, 教授 (70359579)
酒井 光昭 筑波大学, 医学医療系, 講師 (60375508)
兵藤 一行 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (60201729)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 転移性肺腫瘍 / 早期診断 / 放射光血管造影 / ラット / 造影剤 / 放射光 / 肺癌 / 血管造影 / HARP撮像間 / HARP受像管 / 微小癌 / 転移 / 新生血管 |
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| Research Abstract |
Detection of lung cancer is usually performed by chest X-ray or chest computed tomography scan. Minimal size of suspected lung tumor by high resolution CT scan is around 2 or 3 mm. One of the main features of tumor vessel is enhanced permeability across the vessel wall. By use of this property applying contrast material, we tried to find out small metastatic lung tumors employing synchrotron radiation angiography, which equipped high spatial resolution, high density resolution and high time resolution. Rat model of lung metastatic tumor was created using C6 cells. As a result, tumors around 500 um in diameter were recognized. The diagnosis was made effectively based on time-density attenuation curve in suspected tumors comparing with other vessels or background of lung field.
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