| Project/Area Number |
23592054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINO Ichiro 千葉大学, 大学院医学研究院, 教授 (40281547)
YOSHIDA Shigetoshi 千葉大学, 大学院医学研究院, 准教授 (90334200)
SAKAIRI Yuichi 千葉県がんセンター, 医員 (30551949)
IWATA Takekazu 千葉大学, 医学部附属病院, 助教 (30586681)
TAGAWA Tetsuzo 千葉大学, 大学院医学研究院, 助教 (90419557)
SUZUKI Hidemi 千葉大学, 医学部附属病院, 助教 (60422226)
米谷 卓郎 千葉大学, 医学(系)研究科(研究院), 助教 (00452764)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 呼吸器外科学 / 代償性肺成長 / 肺再生 / 肺切除 / 仮想肺組織量 / 再生医療 / II型肺胞上皮 / 肺癌 / 生体肺移植 / 体性幹細胞 / 手術 / COPD |
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| Research Abstract |
It has been generally accepted that lungs cannot regenerate in mature human. After a major lung resection, however, mechanical stretch, shear stress, and a variety of growth factors are induced in the remnant lung, and those are known to be driving forces for compensatory lung growth in animal models. Radiologically estimated "Lung Weight" is focused on as a significant parameter to determine severity of ARDS that is calculated by lung volume and density. Therefore, we also utilized the concept of radiologic estimation of lung weight for evaluation of the compensation. Before clinical investigation, a rational of radiologic lung weight was validated in healthy volunteers. This result met our hypothesis that radiologic lung weight is constant at any respiratory phase. Hypertrophic change of the remnant lung was recognized in living lung donors and lung cancer patients who underwent more than a 10-subsegment resection.
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