| Project/Area Number |
23592056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
BANDO TORU 京都大学, 医学(系)研究科(研究院), 准教授 (20293954)
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| Co-Investigator(Kenkyū-buntansha) |
DATE Hiroshi 京都大学, 大学院医学研究科, 教授 (60252962)
AOYAMA Akihiro 京都大学, 大学院医学研究科, 助教 (60379047)
SATO Masaaki 京都大学, 大学院医学研究科, 助教 (00623109)
黄 政龍 公益財団法人田附興風会, その他部局等, その他 (10271511)
藤永 卓司 京都大学, 医学(系)研究科(研究院), 助教 (00444456)
趙 向東 京都大学, 医学(系)研究科(研究院), 助教 (00444464)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 呼吸器外科 / 移植・再生医療 / トランスレーショナルリサーチ / 外科 |
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| Research Abstract |
We evaluated the effects of continuous perfusion on pulmonary preservation using a rat and a dog ex vivo perfusion models aiming at clinical application of modified ET-K solution as a perfusate. Neither a potassium-reduced ET-K nor an ET-K without HES demonstrated sufficient pulmonary preservation for reliable clinical practice. In addition, supplementation with red blood cells to the perfusion solution also failed to show any significant improvements of the preservation effect. A further extensive modification is needed for the clinical application.
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