| Project/Area Number |
23592057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKAI HIROAKI 京都大学, 医学(系)研究科(研究院), その他 (50362489)
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| Co-Investigator(Kenkyū-buntansha) |
DATE Hiroshi 京都大学, 医学研究科, 教授 (60252962)
SHOJI Tuyoshi 公益財団法人田附興風会, 呼吸器外科, 研 究員 (80402840)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 強制オッシレーション法 / 急性肺拒絶評価 / 肺インピーダンス / tissue fraction / Tissue fraction (TF) / FOT / 急性肺拒絶反応 / lung structure / lung function / 強制オッシレーション / 急性肺拒絶評価法 / 呼吸インピーダンス |
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| Research Abstract |
After lung transplantation, early detection of acute rejection is important for timely and optimal treatment. We examined the relationship between lung mechanics and rejection grade in a rat acute rejection model using the forced oscillation technique (FOT), which provides non-invasive assessment of lung function. We assessed lung resistance and elastance (RL and EL) from implanted left lung of these animals. The rejection severity grade (A-grade) was quantified from histological images using tissue fraction (TF: tissue + cell infiltration area / total area). We found that TF, RL and EL worsened according to A-grade. Both Elow (at lowest frequency of EL) and Ehet (the absolute difference between Elow and maximum value of EL) showed correlation with the mean value of TF. Our results suggest that the dynamic elastance as well as its frequency dependence reflect A-grade. These indexes should prove useful for detecting and monitoring the progression disease in acute rejection.
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