Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Research Abstract |
We detected that expression of miR-34b/c and miR-200c was inhibited in lung cancer. miR-34b/c was more frequently inhibited by methylation in small cell lung cancer. We detected that induction of miR-34b/c showed anti-tumor effect in malignant pleural mesothelioma in vivo. As for miR-200c, its expression was maintained in EGFR-mutant lung cancer cell lines and it was inhibited in EGFR-mutant lung cancer cell line with acquired resistance to EGFR-tyrosine kinase inhibitor (TKI). In addition, epithelial to mesenchymal transition (EMT) was observed in that TKI-resistant cell line. We also confirmed that induction of miR-200c to the TKI-resistant cell line resulted in the termination of EMT.
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