Mechanism and inhibition of ischemia reperfusion injury after lung transplantation from donation after cardiac death

Research Project

Project/Area Number	23592063
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Thoracic surgery
Research Institution	Ehime University
Principal Investigator	OKAZAKI MIKIO 愛媛大学, 医学部附属病院, 講師 (50467750)
Co-Investigator(Kenkyū-buntansha)	SANO Yoshifumi 愛媛大学, 大学院医学系研究科, 准教授 (60322228) YAMANE Masaomi 岡山大学, 医学部附属病院, 助教 (20432643)
Project Period (FY)	2011-04-28 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	肺移植 / 虚血再灌流障害 / 心停止ドナー
Outline of Final Research Achievements	Although lung transplantation from donation after cardiac death (DCD), is limited by warm ischemic periods, the molecular mechanism of warm ischemia-reperfusion-injury (IRI) has not been well elucidated. The purpose of this study was to clarify the particular longitudinal mechanisms of molecular factors involved in warm IRI. This study indicates that anti-inflammatory pathways may play important roles in the graft recovery after lung transplantation from DCD.