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The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung

Research Project

Project/Area Number 23592066
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionNagasaki University

Principal Investigator

TSUCHIYA Tomoshi  長崎大学, 医歯(薬)学総合研究科, 講師 (30437884)

Co-Investigator(Kenkyū-buntansha) NAGAYASU Takeshi  長崎大学, 大学院医歯薬学総合研究科, 教授 (80284686)
SHIMOKAWA Isao  長崎大学, 大学院医歯薬学総合研究科, 教授 (70187475)
YAMASAKI Naoya  長崎大学, 大学院医歯薬学総合研究科, 講師 (70404217)
AKITA Sadanori  長崎大学, 大学病院, 講師 (90315250)
Co-Investigator(Renkei-kenkyūsha) HIGAMI Yoshikazu  東京理科大学, 薬学部, 教授 (90253640)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords虚血再灌流障害 / 肺移植 / 脂肪幹細胞 / PARP inhibitor / 肺虚血再灌流 / ラット肺移植 / PARP阻害剤 / 脂肪肝細胞
Research Abstract

In the starting up study, we established rat ischemia-reperfusion model using hilar clumping. Using the model, we could show that PARP-1 inhibitor prevent the tissue injury. The study was accepted in the journal of Transplantation. In the study of adipose tissue derived stromal cells, we established rat lung transplantation model and used the cells to prevent tissue rejection. Interestingly, adipose tissue derived stromal cells enhanced the effects of immunosuppressant.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014

    • Author(s)
      Go Hatachi, Tomoshi Tsuchiya, Takuro Miyazaki, Keitaro Matsumoto, Naoya Yamasaki, Shingo Matsushima, Atsushi Nanashima, Yoshikazu Higami, and Takeshi Nagayasu
    • Journal Title

      Transplantation

      Volume: (In press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014

    • Author(s)
      Go Hatachi
    • Journal Title

      Transplantation

      Volume: -

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺虚血再灌流障害に対するPARP阻害薬の臓器保護効果の検討2014

    • Author(s)
      畑地 豪
    • Organizer
      日本外科学会総会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺虚血再灌流障害に対するPARP阻害薬PJ34の臓器保護効果の検討2013

    • Author(s)
      畑地豪
    • Organizer
      第40回日本臓器保存生物医学会
    • Place of Presentation
      東京医科大学病院臨床講堂
    • Year and Date
      2013-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Poly(ADP-ribose)polymerase阻害薬は肺の虚血再灌流障害時における抗酸化力を高め、酸化ストレスによる障害を軽減する2013

    • Author(s)
      畑地豪
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2013-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Poly(ADP-ribose) polymerase inhibitor (PJ34) abrogates the oxidative stress induced by pulmonary ischemia-reperfusion injury2013

    • Author(s)
      Go Hatachi
    • Organizer
      ATS 2013 international conference
    • Place of Presentation
      Philadelphia
    • Year and Date
      2013-04-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Poly(ADP-ribose) polymerase inhibitor (PJ34) abrogates the oxidative stress induced by pulmonary ischemia-reperfusion injury2013

    • Author(s)
      畑地 豪
    • Organizer
      American Thoracic Society (ATS) 2013
    • Place of Presentation
      フィラデルフィア(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Poly(ADP-ribose) polymerase inhibitor (PJ34) suppressed the oxidative stress damage induced by pulmonary ischemia-reperfusion injury throughout acute inflammation phase.2013

    • Author(s)
      畑地 豪
    • Organizer
      アジア移植学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Poly(ADP-ribose)polymerase阻害薬は肺の虚血再灌流障害時における抗酸化力を高め、酸化ストレスによる障害を軽減する2013

    • Author(s)
      畑地 豪
    • Organizer
      日本移植学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Poly(ADP-ribose)polymerase阻害薬の臓器保護効果の検討2013

    • Author(s)
      畑地 豪
    • Organizer
      日本臓器保存生物学会
    • Place of Presentation
      東京医科大学(東京都新宿区)
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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