| Project/Area Number |
23592069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
SUZUKI Makoto 熊本大学, 大学院生命科学研究部, 教授 (80312940)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Koei 熊本大学, 医学部附属病院, 助教 (20448525)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 非小細胞肺癌 / 血管新生 / SLIT2 / IRF8 |
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| Research Abstract |
We examined a role of five genes ( LINE-1, SLIT2, MAL, IGFBP7, IRF8 ) including the gene which relates to angigogenesis, in terms of the carcinogenesis and invasion of non-small cell lung cancer (NSCLC). As a result, in NSCLC, LINE-1 was hypomethylated and expressions of other SLIT2, MAL, IGFBP7, and IRF8 were lowered by hypermethylation of their genes. Because the changes were tumor-specific when compared with non-malignant lung tissues, further study will clarify the mechanism of carcinogenesis of NSCLC and will contribute to the new treatment of NSCLC.
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