• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Construction of an artificial trachea using newly developed tissue engineering technique

Research Project

Project/Area Number 23592071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionNara Medical University

Principal Investigator

NAITO HIROSHI  奈良県立医科大学, 医学部, 研究員 (00316069)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords再生医療 / 組織工学 / 人工気管 / 骨芽細胞 / 間葉系幹細胞 / 人工気管組織
Research Abstract

We constructed an artificial trachea, which made from soft tube-shaped tissue and hard ring-shaped tissue, which had similar structure with native trachea. Tube-shaped tissue was constructed from fibroblasts and ring-shaped tissue was constructed from mesenchymal stem cells. Mesenchymal stem cells were induced differentiation into osteoblasts during ring-shaped tissue construction, and this differentiation increased mechanical strength of the tissue. This artificial trachea was transplanted into rat trachea and which showed the potential for usage.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] The advantages of three-dimensional culture in a collagen hydrogel for stem cell differentiation2013

    • Author(s)
      Naito H, Yoshimura M, Mizuno T, Takasawa S, Tojo T, Taniguchi S
    • Journal Title

      J Biomed Mater Res A

      Volume: 101A Pages: 2838-2845

    • Related Report
      2013 Final Research Report
  • [Journal Article] The advantages of three-dimensional culture in a collagen hydrogel for stem cell differentiation.2013

    • Author(s)
      Naito H, Yoshimura M, Mizuno T, Takasawa S, Tojo T, Taniguchi S.
    • Journal Title

      J Biomed Mater Res A

      Volume: Epub ahead of print Issue: 10 Pages: 2838-2845

    • DOI

      10.1002/jbm.a.34578

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi