Construction of an artificial trachea using newly developed tissue engineering technique
Project/Area Number |
23592071
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Thoracic surgery
|
Research Institution | Nara Medical University |
Principal Investigator |
NAITO HIROSHI 奈良県立医科大学, 医学部, 研究員 (00316069)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 再生医療 / 組織工学 / 人工気管 / 骨芽細胞 / 間葉系幹細胞 / 人工気管組織 |
Research Abstract |
We constructed an artificial trachea, which made from soft tube-shaped tissue and hard ring-shaped tissue, which had similar structure with native trachea. Tube-shaped tissue was constructed from fibroblasts and ring-shaped tissue was constructed from mesenchymal stem cells. Mesenchymal stem cells were induced differentiation into osteoblasts during ring-shaped tissue construction, and this differentiation increased mechanical strength of the tissue. This artificial trachea was transplanted into rat trachea and which showed the potential for usage.
|
Report
(4 results)
Research Products
(2 results)