Role of RAGE in peri-operative lung injury

• Project/Area Number: 23592076
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAKUMA Tsutomu 金沢医科大学, 医学部, 教授 (90215674)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: RAGE / 肺傷害 / 肺癌 / 慢性閉塞性肺疾患 / 周術期 / 肺胞水分クリアランス / PPAR / 肺水腫 / 肺胞上皮細胞 / 再潅流肺傷害 / ヒト切除肺 / 肺嚢胞 / 虚血再潅流肺傷害

Research Abstract

The expression of receptor for advanced glycation end products (RAGE) was examined in the excised human lungs. The expression of type 1 alveolar cells and alveolar macrophage increased in chronic obstructive pulmonary disease (COPD). The expression was correlated negatively with forced expiratory volume in one second. RAGE expression was not associated with smoking index. In lung cancer, RAGE was highly expressed in both small cell lung cancer and adenocarcinoma. Less differentiated adenocarcinoma expressed RAGE more frequently than well differentiated adenocarcinoma. The enhanced expression of RAGE was present in non-mucinous adenocarcinoma. Adenocarcinoma in the advanced stages tended to show a higher expression score for RAGE. The expression of RAGE inversely correlated with that of AGEs, although it did not show any relationship with the expression of HMGB-1 or S100A4. In rat lung, PPAR-gamma impaired alveolar fluid clearance probably through amiloride-sensitive sodium channel.

Research Products

• [Journal Article] Comparative Immunohistochemical Analysis of IMP3, GLUT1, EMA, CD146, and Desmin for Distinguishing Malignant Mesothelioma From Reactive Mesothelial Cells (2014)
  • Author(s): Minato H, Kurose N, Fukushima M, Nojima T, Usuda K, Sagawa M, Sakuma T, Ooi A, Matsumoto I, Oda M, Arano Y, Shimizu J
  • Journal Title: Am J Clin Pathol Volume: 141 Pages: 85-93
  • Peer Reviewed
• [Journal Article] Postoperative drainage with one chest tube is appropriate for pulmonary lobectomy : a randomized trial (2014)
  • Author(s): Tanaka M, Sagawa M, Usuda K, Machida Y, Ueno M, Motono N, Sakuma T
  • Journal Title: Tohoku J Exp Med Volume: 232 Pages: 55-61
  • NAID: 130004822395
  • Peer Reviewed
• [Journal Article] Relationships between EGFR Mutation Status of Lung Cancer and Preoperative Factors - Are they Predictive? (2014)
  • Author(s): Usuda K, Sagawa M, Motono N, Ueno M, Tanaka M, Machida Y, Matoba M, Taniguchi M, Tonami H, Ueda Y, Sakuma T
  • Journal Title: Asian Pac J Cancer Prev Volume: 15 Pages: 657-662
  • Peer Reviewed
• [Journal Article] Saline-cooled radiofrequency coagulation during thoracoscopic surgery for giant bulla (2014)
  • Author(s): Sagawa M, Maeda T, Yoshimitsu Y, Sakuma T
  • Journal Title: Eur J Cardiothorac Surg
  • Peer Reviewed
• [Journal Article] Assessment of bispectral index monitor during flexible bronchoscopy performed under conscious sedation (2014)
  • Author(s): Usuda K, Sagawa M, Motono N, Ueno M, Tanaka M, Machida Y, Oikawa T, Saito M, Kojima K, Tahahara Y, Shinomiya S, Yamaya A, Sakuma T
  • Journal Title: The Journal of Japan Society for Respiratory Endoscopy Volume: 36 Pages: 12-19
  • NAID: 110009798810
  • Peer Reviewed
• [Journal Article] 慢性閉塞性肺疾患におけるReceptor for Advanced Glycation End Product蛋白の発現 (2014)
  • Author(s): 田中良
  • Journal Title: 金沢医科大学雑誌
  • Peer Reviewed
• [Journal Article] 原発性肺癌におけるRAGEおよび関連因子の発現 (2014)
  • Author(s): 上野正克
  • Journal Title: 金沢医科大学雑誌
  • Peer Reviewed
• [Journal Article] Translational studies in the ex vivo human lung (2014)
  • Author(s): Sakuma T, Matthay MA
  • Journal Title: Respiration Investigation
• [Journal Article] Advantages of Diffusion-Weighted Imaging Over Positron Emission Tomography-Computed Tomography in Assessment of Hilar and Mediastinal Lymph Node in Lung Cancer (2013)
  • Author(s): Usuda K, Sagawa M, Motono N, Ueno M, Tanaka M, Machida Y, Matoba M, Kuginuki Y, Taniguchi M, Ueda Y, Sakuma T
  • Journal Title: Ann Surg Oncol Volume: 20 Pages: 1676-1683
  • Peer Reviewed
• [Journal Article] Diffusion-weighted imaging (DWI) signal intensity and distribution represent the amount of cancer cells and their distribution in primary lung cancer (2013)
  • Author(s): Usuda K, Zhao XT, Sagawa M, Aikawa H, Ueno M, Tanaka M, Machida Y, Matoba M, Ueda Y, Sakuma T
  • Journal Title: Clin Imaging Volume: 37 Pages: 265-272
  • Peer Reviewed
• [Journal Article] A randomized phase III trial of postoperative adjuvant therapy for completely resected stage IA-IIIA lung cancer using an anti‑angiogenetic agent : irsogladine maleate (2013)
  • Author(s): Sagawa M, Shibuya J, Takahashi S, Endo C, Abiko M, Suzuki H, Matsumura Y, Sakuma T, Sato N, Deguchi H, Nakamura Y, Hasumi T, Kondo T
  • Journal Title: Minerva Chir Volume: 68 Pages: 587-57
  • Peer Reviewed
• [Journal Article] Loss of HITS (FAM107B) expression in cancers of multiple organs : tissue microarray analysis (2012)
  • Author(s): Nakajima H, Koizumi K, Tanaka T, Ishigaki Y, Yoshitake Y, Yonekura H, Sakuma T, Fukushima T, Umehara H, Ueno S, Minamoto T, Motoo Y
  • Journal Title: Int J Oncol Volume: 41 Pages: 1347-1357
  • Peer Reviewed
• [Journal Article] Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency : a prospective observational cohort study (2012)
  • Author(s): Ichikado K, Muranaka H, Gushima Y, Kotani T, Nader HM, Fujimoto K, Johkoh T, Iwamoto N, Kawamura K, Nagano J, Fukuda K, Hirata N, Yoshinaga T, Ichiyasu H, Tsumura S, Kohrogi H, Kawaguchi A, Yoshioka M, Sakuma T, Suga M.
  • Journal Title: BMJ Open Volume: 2(2) Issue: 2 Pages: e000545-e000545
  • DOI: 10.1136/bmjopen-2011-000545
  • Peer Reviewed
• [Journal Article] The JECS Study Group. A Randomized Controlled Trial on the Efficacy of Thoracic CT Screening for Lung Cancer in Non-smokers and Smokers of <30 Pack-years Aged 50-64 Years (JECS Study): Research Design (2012)
  • Author(s): Sagawa M, Nakayama T, Tanaka M, Sakuma T, Sobue T
  • Journal Title: Jpn J Clin Oncol Volume: 42 Pages: 1219-1221
  • Peer Reviewed
• [Journal Article] Significance of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Lung Cancer: correlation of Apparant Diffusion Coefficient Value with Clinicopatological Factors (2012)
  • Author(s): Xiong Zhao
  • Journal Title: J Kanazawa Med Univ Volume: 37 Pages: 35-46
  • Peer Reviewed
• [Journal Article] 肺腺癌の進展におけるアクアポリンの役割 (2012)
  • Author(s): 町田雄一郎
  • Journal Title: 肺癌 Volume: 52 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Significance of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Lung Cancer: correlation of Apparant Diffusion Coefficient Value with Clinicopatological Factors (2012)
  • Author(s): Xitong Zhao
  • Journal Title: Journal of Kanazawa Medical University Volume: 37
  • Peer Reviewed