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Development of novel molecular targeted therapies for the treatment of KRas mutated non small lung cancer using a HSP90 inhibitor

Research Project

Project/Area Number 23592078
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionKawasaki Medical School

Principal Investigator

MORITA ICHIRO  川崎医科大学, 医学部, 准教授 (30200413)

Co-Investigator(Kenkyū-buntansha) 深澤 拓也  川崎医科大学, 医学部, 講師 (20379845)
繁光 薫  川崎医科大学, 医学部, 講師 (50585007)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsKRas / HSP90 / inhibitor / AUY922 / 抗腫瘍効果 / 呼吸器外科学 / 非小細胞性肺癌 / HSP90阻害剤
Research Abstract

Hsp90 inhibitors are substances that inhibit the activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety of proteins required for survival of cancer cells, these substances may have therapeutic benefit in the treatment of various types of malignancies. In the present study, we have evaluated the antitumor effects of a novel HSP90 inhibitor, AUY922 for the treatment of lung cancer. AUY922 suppressed cell viability and induced apoptosis in KRas addicted pulmonary adenocarcinoma cells. More, the inhibitor showed antitumor effect in EGFR-TK mutation or EML4-ALK positive lung cancer cells. These results indicate that AUY922 looks to be a promising treatment for non small cell lung cancer including pulmonary adenocarcinoma harboring KRas mutation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2011 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] Inhibition of Myc Effedtively Targets KRAS Mutation-positive Lung Cancer2011

    • Author(s)
      深澤拓也,山辻知樹,繁光薫,高岡宗徳,木下真一郎,森田一郎,前田豊, Mary Durbin, Soucek Laura,猶本良夫
    • Organizer
      第64回日本胸部外科学会定期学術集会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] K-ras及びMycを標的とした新規非小細胞肺癌治療法の開発2011

    • Author(s)
      深澤拓也,森田一郎,木下真一郎,吉田和弘,山辻知樹,繁光薫,林次郎,松岡順次,前田豊, Durbin Mary, Soucek Laura,猶本良夫
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-11-04
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.kawasaki-m.ac.jp/med/index.html

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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