| Project/Area Number |
23592079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹之山 光広 国立病院機構九州がんセンター, 医学部, 呼吸器腫瘍科医長 (10309966)
浦本 秀隆 産業医科大学, 医学部, 准教授 (90389445)
重松 義紀 産業医科大学, 医学部, 助教 (10546469)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺癌 / 制御性T細胞 / 腫瘍免疫 / 免疫逃避 / 細胞障害性T細胞 / 免疫逃避機構 / 制御性Ｔ細胞 / TGF-β / Foxp3 / 所属リンパ節 / 制御性Tリンパ球 / フローサイトメトリ / リアルタイムPCR |
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| Research Abstract |
Regulatory T cells (Tregs) are potent immunosuppressive cells that play a crucial role in tumor immune escape. The purpose of the present study was to evaluate the prognostic significance of CD4+ CD25+ Foxp3+ Tregs in the regional lymph node lymphocytes (RLNL) in patients who underwent surgical resection of non-small cell lung cancer (NSCLC). The proportions of Tregs in the RLNL were determined by flow cytometry and quantitative RT–PCR. The 5-year survival rate was significantly better in patients with the lower proportion of Tregs than that in the higher patients. The higher proportion of Tregs in the RLNL was a significant unfavorable prognostic factor in NSCLC. The information about the proportion of Tregs in the RLNL is considered to be important to overcome the tumor immune escape for development of the effective adjuvant immunotherapy
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