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Innovation of safety treatment method for cerebral infarction: Application of Staphylokinase

Research Project

Project/Area Number 23592082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionHirosaki University

Principal Investigator

SHIMAMURA Norihito  弘前大学, 医学(系)研究科(研究院), 講師 (40312491)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsスタフィロキナーゼ / 心原性脳塞栓症 / 脳梗塞 / ラット / 脳塞栓 / tPA / SAK / 脳塞栓症
Research Abstract

Ischemic rats were produced by inserting a blood clot into the internal carotid artery (ICA). We applied t-PA, SAK or PBS via an intravenous route 30 minutes after stroke. Neurological status was checked after 24 hours. The infarction volumes were measured using the TTC method. One rat in the PBS group died of infarction and two rats died due to respiratory difficulties in the t-PA group. Two t-PA treated rats, two PBS treated rats and one SAK treated rat revealed hemorrhagic infarction. Mean infarction volumes of the cortex were 112mm in the t-PA group, 132mm in the SAK group and 256mm in the PBS group (p < 0.05). Mean neurological scores were 6.1 in the t-PA group, 7.7 in the SAK group and 9.2 in the PBS group (p < 0.05). SAK showed low risk of hemorrhagic infarction and respiratory difficulties. Its ability to improve neurological scores and reduce cortical infarctions was below that of t-PA.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Safety of preprocedural antiplatelet medication in coil embolization of ruptured cerebral aneurysms at the acute stage2014

    • Author(s)
      Norihito Shimamura、Masato Naraoka、Naoya Matsuda、Hiroki Ohkuma
    • Journal Title

      Interventional Neuroradiolgy

      Volume: (In print)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Phenotypic Transformation of Smooth Muscle in Vasospasm after Aneurysmal Subarachnoid Hemorrhage2014

    • Author(s)
      Norihito Shimamura、Hiroki Ohkuma
    • Journal Title

      Transl Stroke Res

      Volume: 5 Issue: 3 Pages: 357-364

    • DOI

      10.1007/s12975-013-0310-1

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Safety of preprocedural antiplatelet medication in coil embolization of ruptured cerebral aneurysms at the acute stage2014

    • Author(s)
      Norihito Shimamura, Masato Naraoka, Naoya Matsuda, Hiroki Ohkuma
    • Journal Title

      Interventional Neuroradiology

      Volume: XX

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Model of Rat Embolic Cerebral Infarction with a Quantifiable, Autologous Arterial Blood Clot2013

    • Author(s)
      Norihito Shimamura, Naoya Matsuda, Kiyohide Kakuta, Akiko Narita, Hiroki Ohkuma
    • Journal Title

      Transl Stroke Res

      Volume: 4 Issue: 5 Pages: 564-570

    • DOI

      10.1007/s12975-013-0262-5

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] スタフィロキナーゼはラット脳塞栓モデルにおいて脳梗塞巣を軽減する2014

    • Author(s)
      嶋村則人
    • Organizer
      第39回日本脳卒中学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Recombinant staphylokinase reduces the volume of cerebral infarction in a rat thromboembolic ischemia model2014

    • Author(s)
      Norihito Shimamura
    • Organizer
      The 2nd International Conference on Heart & Brain
    • Place of Presentation
      フランス
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] A model of rat embolic internal carotid artery occlusion with a quantifiable, autologous arterial blood clot2013

    • Author(s)
      Norihito Shimamura
    • Organizer
      26th International Symposium of Cerebral Blood Flow, Metabolism and Function
    • Place of Presentation
      中国
    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
  • [Presentation] 定量的自家血栓によるラット心原性脳塞栓モデルの開発2013

    • Author(s)
      嶋村則人
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 定量的自家血栓によるラット心原性脳塞栓 モデルの開発2013

    • Author(s)
      嶋村 則人
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 血管内手技を応用した動物実験科学2012

    • Author(s)
      嶋村則人
    • Organizer
      第28回日本脳神経血管内治療学会
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管内手技を応用した 動物実験科学2012

    • Author(s)
      嶋村 則人
    • Organizer
      第28回日本脳神経血管内治療学会
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2012 Research-status Report
  • [Remarks] 弘前大学大学院医学研究科脳神経外科ホームページ

    • URL

      http://www.med.hirosaki-u.ac.jp/~neuros/

    • Related Report
      2013 Final Research Report
  • [Remarks] 弘前大学大学院医学研究科脳神経外科

    • URL

      http://www.med.hirosaki-u.ac.jp/~neuros/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 弘前大学医学部脳神経外科

    • URL

      http://www.med.hirosaki-u.ac.jp/~neuros/index.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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