| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron containing liposome. The liposome is expected that have EPR effect and adhesive property by sizing and surface modification. Cells were cultured with B containing medium, and neutron irradiation revealed the radiobiological effect of boron neutron capture. borocaptate sodium solution was encapsulated in this liposome, then it achieves the 2.5 times higher boron concentration than nano-particle only.
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