Prevention of Vascular Restenosis After Vascular Angioplasty by Endothelial specific BNCT
| Project/Area Number |
23592084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Akira 筑波大学, 医学医療系, 教授 (90241819)
YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505)
YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脳血管内外科学 / ホウ素中性子捕捉療法 / リポソーム / ホウ素送達システム / 血管内皮 / 血管形成術 / 再狭窄 |
|---|
| Research Abstract |
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron containing liposome. The liposome is expected that have EPR effect and adhesive property by sizing and surface modification. Cells were cultured with B containing medium, and neutron irradiation revealed the radiobiological effect of boron neutron capture. borocaptate sodium solution was encapsulated in this liposome, then it achieves the 2.5 times higher boron concentration than nano-particle only.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] ntra-tumor Distribution of Metallofullerene Using Micro-particle induced X-ray Emission (PIXE)2014
Author(s)
Y. Yamamoto, T. Yamamoto, Y. Horiguchi, K. Endo, M. Shirakawa, T. Miyakawa , A. Matsumura H. Satoh, M. Koka, K. Nakai, Y. Nagasaki, A. Matsumura
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Journal Title
Applied Radiation and isotope
Volume: 88
Pages: 114-117
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma : a recursive partitioning analysis of BNCT patients2011
Author(s)
Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, Kumada H, Isobe T, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Mizumoto M, Tsuboi K, Matsumura A
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Journal Title
Appl Radiat Isot
Volume: 69
Issue: 12
Pages: 1790-1792
DOI
Related Report
Peer Reviewed
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