The roles of epigenetic mechanism in cerebral ischemic preconditioning

Research Project

Project/Area Number	23592088
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	University of Yamanashi
Principal Investigator	YOSHIOKA Hideyuki 山梨大学, 医学部附属病院, 助教 (20402076)
Co-Investigator(Kenkyū-buntansha)	KINOUCHI Hiroyuki 山梨大学, 医学工学総合研究部, 教授 (30241623)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	脳虚血耐性 / 虚血性神経細胞傷害 / エピジェネティクス / 脳虚血耐性現象
Research Abstract	Epigenetic mechanism such as DNA methylation and modifications of histone proteins controls heritable change in gene expression. On the other hand, ischemic preconditioning involves numerous gene expression changes; however, its mechanism is still obscure. In this study, we evaluated the roles of epigenetic mechanism in ischemic preconditioning. Our results show that methylation of histone proteins was modified, and gene expressions related to apoptosis and inflammation were down-regulated in the preconditioned brains. Further studies are necessary to clarify the relationship between epigenetic mechanism and gene expression changes.