| Project/Area Number |
23592091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURISU Kaoru 広島大学, 医歯薬保健学研究院, 教授 (70201473)
YAMASAKI Fumiyuki 広島大学, 医歯薬保健学研究院, 助教 (60444692)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | glioma / glioblastoma / pseudo-response / DWI / proton MR spectroscopy / ADC / VEGF / RANO / bevacizumab / temozolomide / SWI / lymphoma / high b-value / pseudo-progression / oligodendroglial tumor |
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| Research Abstract |
The single voxel 1HMRS detection of lactate is a prognostic factor in patients with diffuse intrinsic pontine glioma. Calculating the apparent diffusion coefficient value is useful for distinguishing lymphoma from glioblastoma. High b-value DWI reflects cell density more accurately than regular b-value DWI at 3 tesla MRI. It was easier to identify pseudo-responses with RANO- than MacDonald criteria, however the reduction of edema by bevacizumab rendered the early diagnosis of tumor progression difficult by RANO criteria. In some patients with recurrent glioma treated with bevacizumab, high b-value DWI criteria did, while McDonald- and RANO criteria did not identify pseudo-responses at an early point after the start of therapy. In patients with recurrent glioma, high b-value DWI criteria are useful for the differentiation between pseudo- and true responses to treatment with bevacizumab.
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