Basic analysis of bone marrow derived mesenchymal stem cells for transplantation immunology

Research Project

Project/Area Number	23592101
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	Sapporo Medical University
Principal Investigator	WANIBUCHI Masahiko 札幌医科大学, 医学部, 准教授 (30343388)
Project Period (FY)	2011-04-28 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	骨髄間葉系幹細胞 / 間葉系幹細胞 / 幹細胞 / mesenchymal stem cell / transplantation / immunity
Outline of Final Research Achievements	Immunological analyses for human bone marrow derived mesenchymal stem cells was performed during study period. 1) Gene expression and cell surface marker molecules were analyzed in human bone marrow or peripheral blood derived mesenchymal stem cells. 2) Gene expression and cell surface marker molecules were analyzed in human bone marrow mesenchymal stem cells cultured various conditions. 3) Safety and therapeutic efficacy were evaluated in experimental stroke model after intravenous infusion of mesenchymal stem cells in rats.

Report

(5 results)