Inflammation and platelet aggregation may be related to delayed ischemic neurological deficits after subarachnoid hemorrhage
| Project/Area Number |
23592103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | くも膜下出血 / 脳血管攣縮 / 食欲 / アドレノメデュリン / 炎症 / 血小板 / グレリン / レプチン / 食欲低下 |
|---|
| Research Abstract |
Adrenomedullin (AM) is secreted into the cerebrospinal fluid (CSF) from the choroid plexus and regulates appetite. AM concentration in the CSF is elevated 7–10 days after the onset of aneurysmal subarachnoid hemorrhage (SAH). All outcome variables were measured at an early (Day 3) and late (Day 8) time point after SAH onset (Day 0). Dietary oral calorie intake, self-reported appetite level, hemoglobin, albumin, glucose, and insulin levels were lower at the late time point than at the early time point. CSF AM concentration was higher at the late time point than at the early time point. There was a significant negative correlation between AM concentration and dietary oral calorie intake and self-reported appetite level at the late time point. Six patients (27%) developed DIND. AM concentration at the late time point was significantly higher in patients who developed DIND than in patients who did not. CSF AM concentration 8 days after SAH onset is related to appetite loss and DIND.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Combination of blood flow asymmetry in the cerebral and cerebellar hemispheres on brain perfusion SPECT predicts 5-year outcome in patients with symptomatic unilateral major cerebral artery occlusion.2014
Author(s)
Nomura J, Ogasawara K, Saito H, Terasaki K, Matsumoto Y, Takahashi Y, Ogasawara Y, Saura H, Yoshida K, Sato Y, Kubo Y, Ogawa A
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Journal Title
Neurol Res.
Volume: 36(3)
Issue: 3
Pages: 262-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Postoperative increase in cerebral white matter fractional anisotropy on diffusion tensor magnetic resonance imaging is associated with cognitive improvement after uncomplicated carotid endarterectomy : tract-based spatial statistics analysis2013
Author(s)
Sato Y, Ito K, Ogasawara K, Sasaki M, Kudo K, Murakami T, Nanba T, Nishimoto H, Yoshida K, Kobayashi M, Kubo Y, Mase T, Ogawa A
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Journal Title
Neurosurgery
Volume: 73(4)
Pages: 592-8
Related Report
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[Journal Article] Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion : comparison of brain SPECT and PET imaging2013
Author(s)
Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 40(10)
Pages: 1573-81
Related Report
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[Journal Article] Postoperative changes in cerebral metabolites associated with cognitive improvement and impairment after carotid endarterectomy : a 3T proton MR spectroscopy study2013
Author(s)
Saito H, Ogasawara K, Nishimoto H, Yoshioka Y, Murakami T, Fujiwara S, Sasaki M, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Ogawa A
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Journal Title
AJNR Am Neuroradiol
Volume: 34(5)
Pages: 976-82
Related Report
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[Journal Article] Postoperative increase in cerebral white matter fractional anisotropy on diffusion tensor magnetic resonance imaging is associated with cognitive improvement after uncomplicated carotid endarterectomy: tract-based spatial statistics analysis.2013
Author(s)
Sato Y, Ito K, Ogasawara K, Sasaki M, Kudo K, Murakami T, Nanba T, Nishimoto H, Yoshida K, Kobayashi M, Kubo Y, Mase T, Ogawa A
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Journal Title
Neurosurgery.
Volume: 73(4)
Issue: 4
Pages: 592-8
DOI
Related Report
Peer Reviewed
-
[Journal Article] Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: comparison of brain SPECT and PET imaging.2013
Author(s)
Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
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Journal Title
Eur J Nucl Med Mol Imaging.
Volume: 40(10)
Issue: 10
Pages: 1573-81
DOI
Related Report
Peer Reviewed
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[Journal Article] Accuracy of central benzodiazepine receptor binding potential/cerebral blood flow SPECT imaging for detecting misery perfusion in patients with unilateral major cerebral artery occlusive diseases : comparison with cerebrovascular reactivity to acetazolamide and cerebral blood flow SPECT imaging2012
Author(s)
Kuroda H, Ogasawara K, Suzuki T, Chida K, Aso K, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Ogawa A
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Journal Title
Clin Nucl Med
Volume: 37(3)
Pages: 235-40
Related Report
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[Journal Article] Postoperative Changes in Cerebral Metabolites Associated with Cognitive Improvement and Impairment after Carotid Endarterectomy: A 3T Proton MR Spectroscopy Study.2012
Author(s)
Saito H, Ogasawara K, Nishimoto H, Yoshioka Y, Murakami T, Fujiwara S, Sasaki M, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Ogawa A.
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Journal Title
AJNR Am J Neuroradiol.
Volume: 2012
Related Report
Peer Reviewed
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[Journal Article] Accuracy of central benzodiazepine receptor binding potential/cerebral blood flow SPECT imaging for detecting misery perfusion in patients with unilateral major cerebral artery occlusive diseases: comparison with cerebrovascular reactivity to acetazolamide and cerebral blood flow SPECT imaging.2012
Author(s)
Kuroda H, Ogasawara K, Suzuki T, Chida K, Aso K, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Ogawa A.
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Journal Title
Clin Nucl Med.
Volume: 37(3)
Pages: 235-240
Related Report
Peer Reviewed
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