| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Adrenomedullin (AM) is secreted into the cerebrospinal fluid (CSF) from the choroid plexus and regulates appetite. AM concentration in the CSF is elevated 7–10 days after the onset of aneurysmal subarachnoid hemorrhage (SAH). All outcome variables were measured at an early (Day 3) and late (Day 8) time point after SAH onset (Day 0). Dietary oral calorie intake, self-reported appetite level, hemoglobin, albumin, glucose, and insulin levels were lower at the late time point than at the early time point. CSF AM concentration was higher at the late time point than at the early time point. There was a significant negative correlation between AM concentration and dietary oral calorie intake and self-reported appetite level at the late time point. Six patients (27%) developed DIND. AM concentration at the late time point was significantly higher in patients who developed DIND than in patients who did not. CSF AM concentration 8 days after SAH onset is related to appetite loss and DIND.
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