The protective effect of Statin for early brain injury after subarachnoid hemorrhage

• Project/Area Number: 23592104
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Jichi Medical University
• Principal Investigator: KUSAKA Gen 自治医科大学, 医学部, 准教授 (00265258)
• Co-Investigator(Kenkyū-buntansha): ISHIKAWA Sane 自治医科大学, 医学部, 教授 (70112620)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: くも膜下出血 / 脳浮腫 / 脳血液関門 / スタチン

Outline of Final Research Achievements

Vascular endothelial growth factor (VEGF) is known as one of the protein which may induce the brain edema. Few studies have examined the relationship between VEGF and early brain injury after subarachnoid hemorrhage (SAH). Using a rat SAH model, we explored the protective effect of Statin (HMG-CoA reductase inhibitors) for early brain injury after SAH related by VEGF-expression. Male Sprangue-Dawly rats weighting 300 to 350g were used for the experimental SAH model. The brain edema, neurological score and VEGF-expression in the cerebral cortex were evaluated at 24 hours after SAH. Experimental SAH induced brain edema, neurological deterioration and over expression of VEGF in the cerebral cortex, while in model rats treated by Statin, the brain edema, neurological score and over expression of VEGF were improved. The author conclude that Statin might offer new treatment strategies for SAH.