Induction of spreading depression by transcranial magnetic stimulation and noninvasive acquisition of ischemic tolerance of brain

• Project/Area Number: 23592105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Saitama Medical University
• Principal Investigator: KOBAYASHI Masahito 埼玉医科大学, 医学部, 准教授 (60245511)
• Co-Investigator(Kenkyū-buntansha): HORIGUCHI Takashi 慶應義塾大学, 医学部, 講師 (70245520)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 脳虚血耐性 / 皮質拡散抑制 / 経頭蓋磁気刺激 / spreading depression

Research Abstract

We have examined the condition of transcranial magnetic stimulation to induce SD in the experimental animal model. With thea burst method (trains of three stimuli of 50 Hz were repeated 5 times in a second) SD was induced most constantly. And this method seems to induce tolerance to the transient ischemia of the brain.

Research Products

• [Journal Article] Preoperative assessment of hemifacial spasm by the coronal heavily T2-weighted MR cisternography. (2014)
  • Author(s): Ohta M, Kobayashi M, Wakiya K, Takamizawa S, Niitsu M, Fujimaki T
  • Journal Title: Acta Neurochir (Wien) Volume: 156 Issue: 3 Pages: 565-569
  • DOI: 10.1007/s00701-013-1941-4
  • Peer Reviewed
• [Journal Article] Speech-induced modulation of interhemispheric inhibition (2012)
  • Author(s): Tadashige Kano, Masahito Kobayashi, Takayuki Ohira, Kazunari Yoshida
  • Journal Title: Neuroscience Letters Volume: 531 Issue: 2 Pages: 86-90
  • DOI: 10.1016/j.neulet.2012.10.027
  • Peer Reviewed
• [Journal Article] Long-term surgical outcome and biological prognostic factors in patients with skull base meningiomas (2011)
  • Author(s): Shigeo Ohba, Masahito Kobayashi, Takashi Horiguchi, Satoshi Onozuka, Kazunari Yoshida, Takayuki Ohira, Takeshi Kawase
  • Journal Title: J Neurosurg Volume: 114巻 Issue: 5 Pages: 1278-1287
  • DOI: 10.3171/2010.11.jns10701
  • Peer Reviewed
• [Presentation] 磁気刺激と言語・認知機能- 研究と臨床応用 (2014)
  • Author(s): 小林正人
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知県立県民文化ホール
  • Invited
• [Presentation] 磁気刺激と言語・認知機能-研究と臨床応用 (2013)
  • Author(s): 小林正人
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知県立県民文化ホール
  • Year and Date: 2013-11-07
  • Invited
• [Presentation] Repetitive transcranial magnetic stimulation once a week induces sustainable long-term relief of post-stroke central pain (2013)
  • Author(s): 小林正人
  • Organizer: International stroke conference
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2013-02-06
• [Presentation] Repetitive transcranial magnetic stimulation once a week induces sustainable long-term relief of post-stroke central pain (2013)
  • Author(s): Masahito Kobayashi
  • Organizer: Internationa stroke conference
  • Place of Presentation: Hawaii, USA
• [Presentation] 経頭蓋磁気刺激による脳卒中後難治性疼痛に対する治療の試み (2012)
  • Author(s): 小林正人
  • Organizer: 第37回脳卒中学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-04-27
• [Presentation] より低侵襲で確実な脳深部刺激電極植え込み術のための我々の工夫 (2012)
  • Author(s): 小林正人
  • Organizer: 第51回日本定位・機能神経外科学会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2012-01-21
• [Presentation] 経頭蓋磁気刺激による脳卒中後難治性疼痛に対する治療の試み (2012)
  • Author(s): 小林正人
  • Organizer: 第37回脳卒中学会総会
  • Place of Presentation: 福岡
• [Presentation] 経頭蓋磁気刺激による脳卒中後の難治性疼痛に対する治療の試み (2011)
  • Author(s): 小林正人
  • Organizer: 第41回日本臨床神経生理学会学術大会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2011-11-10
  • Invited
• [Presentation] 術後残存頭蓋底髄膜腫に対するガンマナイフの治療:脳神経温存と再発防止 (2011)
  • Author(s): 小林正人
  • Organizer: 日本脳神経外科学会第70回総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-10-13
• [Presentation] Correlation between intracortical inhibition and clinical symptoms after STN-DBS in Parkinson'sdisease : TMS study (2011)
  • Author(s): 小林正人
  • Organizer: 8th Meeting of the Asian Australasian Society of Stereotacticand Functional Neurosurgeons
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-06-17
• [Presentation] Correlation between intracortical inhibition and clinical symptoms after STN-DBS in Parkinson’s disease: TMS study
  • Author(s): 小林正人
  • Organizer: 8th Meeting of the Asian Australasian Society of Stereotactic and Functional Neurosurgeons
  • Place of Presentation: Jeju, Korea
• [Presentation] 術後残存頭蓋底髄膜腫に対するガンマナイフの治療：脳神経温存と再発防止
  • Author(s): 小林正l
  • Organizer: 日本脳神経外科学会第70回総会
  • Place of Presentation: 横浜（パシフィコ横浜）
• [Presentation] 経頭蓋磁気刺激による脳卒中後の難治性疼痛に対する治療の試み
  • Author(s): 小林正人
  • Organizer: 第41回日本臨床神経生理学会学術大会(招待講演)
  • Place of Presentation: 静岡（グランシップ 静岡県コンベンションアーツセンター）
• [Presentation] より低侵襲で確実な脳深部刺激電極植え込み術のための我々の工夫
  • Author(s): 小林正人
  • Organizer: 第51回日本定位・機能神経外科学会
  • Place of Presentation: 東京（東京ステーションコンファレンス）