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Induction of spreading depression by transcranial magnetic stimulation and noninvasive acquisition of ischemic tolerance of brain

Research Project

Project/Area Number 23592105
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSaitama Medical University

Principal Investigator

KOBAYASHI Masahito  埼玉医科大学, 医学部, 准教授 (60245511)

Co-Investigator(Kenkyū-buntansha) HORIGUCHI Takashi  慶應義塾大学, 医学部, 講師 (70245520)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords脳虚血耐性 / 皮質拡散抑制 / 経頭蓋磁気刺激 / spreading depression
Research Abstract

We have examined the condition of transcranial magnetic stimulation to induce SD in the experimental animal model. With thea burst method (trains of three stimuli of 50 Hz were repeated 5 times in a second) SD was induced most constantly. And this method seems to induce tolerance to the transient ischemia of the brain.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results) (of which Invited: 3 results)

  • [Journal Article] Preoperative assessment of hemifacial spasm by the coronal heavily T2-weighted MR cisternography.2014

    • Author(s)
      Ohta M, Kobayashi M, Wakiya K, Takamizawa S, Niitsu M, Fujimaki T
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 156 Issue: 3 Pages: 565-569

    • DOI

      10.1007/s00701-013-1941-4

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Speech-induced modulation of interhemispheric inhibition2012

    • Author(s)
      Tadashige Kano, Masahito Kobayashi, Takayuki Ohira, Kazunari Yoshida
    • Journal Title

      Neuroscience Letters

      Volume: 531 Issue: 2 Pages: 86-90

    • DOI

      10.1016/j.neulet.2012.10.027

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term surgical outcome and biological prognostic factors in patients with skull base meningiomas2011

    • Author(s)
      Shigeo Ohba, Masahito Kobayashi, Takashi Horiguchi, Satoshi Onozuka, Kazunari Yoshida, Takayuki Ohira, Takeshi Kawase
    • Journal Title

      J Neurosurg

      Volume: 114巻 Issue: 5 Pages: 1278-1287

    • DOI

      10.3171/2010.11.jns10701

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 磁気刺激と言語・認知機能- 研究と臨床応用2014

    • Author(s)
      小林正人
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化ホール
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 磁気刺激と言語・認知機能-研究と臨床応用2013

    • Author(s)
      小林正人
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化ホール
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Repetitive transcranial magnetic stimulation once a week induces sustainable long-term relief of post-stroke central pain2013

    • Author(s)
      小林正人
    • Organizer
      International stroke conference
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2013-02-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Repetitive transcranial magnetic stimulation once a week induces sustainable long-term relief of post-stroke central pain2013

    • Author(s)
      Masahito Kobayashi
    • Organizer
      Internationa stroke conference
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 経頭蓋磁気刺激による脳卒中後難治性疼痛に対する治療の試み2012

    • Author(s)
      小林正人
    • Organizer
      第37回脳卒中学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] より低侵襲で確実な脳深部刺激電極植え込み術のための我々の工夫2012

    • Author(s)
      小林正人
    • Organizer
      第51回日本定位・機能神経外科学会
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2012-01-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 経頭蓋磁気刺激による脳卒中後難治性疼痛に対する治療の試み2012

    • Author(s)
      小林正人
    • Organizer
      第37回脳卒中学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 経頭蓋磁気刺激による脳卒中後の難治性疼痛に対する治療の試み2011

    • Author(s)
      小林正人
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 術後残存頭蓋底髄膜腫に対するガンマナイフの治療:脳神経温存と再発防止2011

    • Author(s)
      小林正人
    • Organizer
      日本脳神経外科学会第70回総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlation between intracortical inhibition and clinical symptoms after STN-DBS in Parkinson'sdisease : TMS study2011

    • Author(s)
      小林正人
    • Organizer
      8th Meeting of the Asian Australasian Society of Stereotacticand Functional Neurosurgeons
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2011-06-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlation between intracortical inhibition and clinical symptoms after STN-DBS in Parkinson’s disease: TMS study

    • Author(s)
      小林正人
    • Organizer
      8th Meeting of the Asian Australasian Society of Stereotactic and Functional Neurosurgeons
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] 術後残存頭蓋底髄膜腫に対するガンマナイフの治療:脳神経温存と再発防止

    • Author(s)
      小林正l
    • Organizer
      日本脳神経外科学会第70回総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2011 Research-status Report
  • [Presentation] 経頭蓋磁気刺激による脳卒中後の難治性疼痛に対する治療の試み

    • Author(s)
      小林正人
    • Organizer
      第41回日本臨床神経生理学会学術大会(招待講演)
    • Place of Presentation
      静岡(グランシップ 静岡県コンベンションアーツセンター)
    • Related Report
      2011 Research-status Report
  • [Presentation] より低侵襲で確実な脳深部刺激電極植え込み術のための我々の工夫

    • Author(s)
      小林正人
    • Organizer
      第51回日本定位・機能神経外科学会
    • Place of Presentation
      東京(東京ステーションコンファレンス)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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