| Project/Area Number |
23592107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIDEKI Atsumi 東海大学, 医学部, 講師 (30307269)
KAGAYAKI Kuroda 東海大学, 情報理工学部, 教授 (70205243)
YUTAKA Imai 東海大学, 医学部, 研究者番号 (70138113)
MASAAKI Imai 東海大学, 医学部, 助教 (30459424)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | MRI / 温度計測 / レーザー治療 / 化学療法 / 画像情報 / 脳腫瘍 / 温熱治療 / レーザー / DDS / 抗がん剤治療 |
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| Research Abstract |
MR temperature measurement using the water proton chemical shift technique represents a promising method for temperature monitoring in vivo. The novel diffuse- projection ®ber is clearly visualized in different optical penetrations upon MR temperature measurement. We detected the serious problem of carbonization around the laser ®ber tip and during LITT, and herein described a combination of two methodologies that regulated tempera- ture during LITT using MR temperature monitoring to reduce this risk of carbonization: the combined use of a diffuse-projection ®ber and the intermittent irradiation method. Temperature measurement by MR not only evaluates the temperature pro®les obtained by different ®ber systems, but also determines the appropriate irradia- tion method for the treatment of intracranial lesions.
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