Clinical implication of biomarker for patients with acute stroke

• Project/Area Number: 23592110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: YOKOTA Chiaki 独立行政法人国立循環器病研究センター, 病院, 医長 (80300979)
• Co-Investigator(Kenkyū-buntansha): KOKUBO Yoshihiro 独立行政法人国立循環器病研究センター, 病院, 医長 (20393217)
• Co-Investigator(Renkei-kenkyūsha): SAWAMURA Tatsuya 独立行政法人国立循環器病研究センター, 研究所, 部長 (30243033) ; NISHIMURA Kunihiro 独立行政法人国立循環器病研究センター, 開発基盤センター, 室長 (70397834) ; HIROKAWA Go 独立行政法人国立循環器病研究センター, 研究所, 室長 (90450890)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 終末糖化産物受容体関連物質 / ペントシジン / LOX-1 / 吹田コホート / 急性脳卒中 / 急性期脳卒中 / カットオフ値 / バイオマーカー / sRAGE / esRAGE / ケース・コントロール研究

Research Abstract

A secreted isoform of receptor for advanced glycation end products (sRAGE) involves sRAGE and endogenous sRAGE (esRAGE). Pentosidine is one of an advanced glycation end product (AGE). Lectin-like oxidized LDL receptor 1 is responsible for the uptake of oxidized LDL and is released to serum in part as the soluble form (sLOX-1). Few studies addressed the pivotal roles of the AGEs-RAGE system or sLOX-1 in acute stroke patients. We measured plasma sRAGE/esRAGE, pentosidine, and sLOX-1 levels associated with clinical features in acute stroke. Both plasma sRAGE and esRAGE levels correlated with estimated glomerular filtration rate. Higher levels of plasma pentosidine compared with normal were demonstrated in patients with acute stroke. The cut off value 114 pmol/mL of pentosidine has high sensitivity (0.798) and specificity (0.800) for acute stroke. High level of sLOX-1 was examined within a week after the onset of ischemic stroke, however, they decreased at 3 month.

Research Products

• [Journal Article] Predictors of an increase in the number of crebral microbleeds after a first-ever stroke (2012)
  • Author(s): Itabashi R, Yokota C, Yakushiji Y, Minematsu K
  • Journal Title: Euro J of internal Med Volume: 23
  • Peer Reviewed
• [Journal Article] Predictors of an increase in the number of cerebral microbleeds after a first-ever stroke (2012)
  • Author(s): Itabashi R, Yokota C, Yakushiji Y, Minematsu K
  • Journal Title: European J Internal Medicine Volume: 23
• [Journal Article] High level of plasma adiponectin in acute stroke patients is associated with stroke mortality (2011)
  • Author(s): Nagasawa H, Yokota C, Toyoda K, Ito A, Minematsu K
  • Journal Title: J Neurol Sci Volume: 304 Pages: 102-106
  • Peer Reviewed
• [Presentation] 急性期脳梗塞例における血中ペントシジンの臨床的意義:吹田研究との比較 (2013)
  • Author(s): 横田千晶,小久保喜弘,宮本恵宏,豊田一則,峰松一夫
  • Organizer: 第25回日本脳循環代謝学会総会
  • Place of Presentation: 札幌
• [Presentation] 急性期脳梗塞例における血中ペントシジンの臨床的意義：吹田研究との比較. (2013)
  • Author(s): 横田千晶, 小久保喜弘, 宮本恵宏, 豊田一則, 峰松一夫
  • Organizer: 第25回日本脳循環代謝学会総会
  • Place of Presentation: 札幌
• [Presentation] Elevated Serum Soluble Lectin-like Oxidized LDL Receptor-1 (sLOX1) is Associated With Increased Ischemic Stroke Risk : A Case-control Study. International Stroke Conference (2012)
  • Author(s): Fukuda M, Yokota C, Kokubo Y, Sawamura T, Miyamoto Y, Toyoda K, Minematsu K
  • Organizer: New Orleans
  • Place of Presentation: USA
• [Presentation] Clinical implications of plasma pentosidine in acute ischemic stroke (2012)
  • Author(s): Yokota C, Fukuda M, Kokubo Y, Miyamoto Y, Toyoda K, Minemtsu K
  • Organizer: Asia Pacific Stroke Conference
  • Place of Presentation: Tokyo, Japan
• [Presentation] 急性期脳梗塞例における血中ペントシジン値の臨床的意義 (2012)
  • Author(s): 横田千晶、福田真弓、小久保喜弘、宮本恵宏、豊田一則、峰松一夫
  • Organizer: 第37回日本脳卒中学会総会
  • Place of Presentation: 福岡
• [Presentation] 急性期脳梗塞例における血中終末糖化産物ペントシジン値の臨床的意義 (2012)
  • Author(s): 横田千晶,福田真弓,小久保喜弘,豊田一則,峰松一夫
  • Organizer: 第24回日本脳循環代謝学会総会
  • Place of Presentation: 広島
• [Presentation] Clinical implications of plasma pentosidine in acute ischemic stroke (2012)
  • Author(s): Yokota C, Fukuda M, Kokubo Y, Miyamoto Y, Toyoda K, Minematsu K
  • Organizer: Asia Pacific Stroke Conference 2012
  • Place of Presentation: Tokyo, Japan
• [Presentation] 血中可溶型LOX-1高値は脳梗塞の発症と関連する (2012)
  • Author(s): 福田真弓, 横田千晶, 小久保喜弘, 沢村達也, 宮本恵宏, 豊田一則, 峰松一夫:
  • Organizer: 第37回日本脳卒中学会総会
  • Place of Presentation: 福岡
• [Presentation] Clinical implications for soluble forms of receptor for advanced glycation end products (RAGE) in patients with acute ischemic stroke (2011)
  • Author(s): Yokota C, Fukuda M, Sato K, Toyoda K, Minematsu K
  • Organizer: XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function & Xth International
  • Place of Presentation: Conference. Barcelona, Spain
• [Presentation] 可溶性終末糖化産物受容体sRAGE, esRAGEはバイオマーカーとなりえるか:急性期脳卒中例での検討 (2011)
  • Author(s): 横田千晶、福田真弓、佐藤和明、豊田一則、峰松一夫
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: 京都
• [Presentation] Clinical implications for soluble forms of receptor for advanced glycation end products (RAGE) in patients with acute ischemic stroke.
  • Author(s): Yokota C, Fukuda M, Sato K, Toyoda K, Minematsu K
  • Organizer: XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function & Xth International . Conference.
  • Place of Presentation: Barcelona, Spain
• [Remarks] 国立循環器病研究センター 脳血管内科紹介
  • URL: http://hospital.ncvc.go.jp/section/f001/f001-a.html