Malignant glioma absorption therapy with radiation therapy
| Project/Area Number |
23592111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロティオグリカン / 悪性グリオーマ / 細胞吸着療法 / 放射線治療 / プロテオグリカン / グリオーマ |
|---|
| Research Abstract |
If we would protect glioma cell invasion and gather one part, we could threat them more effective. After proteoglycan artificial matrix with molecular target medicine AG1478 were completed, tumor cells were absorbed in artificial matrix. After that, when radiotherapy was done, tumor cell would be killed effectively. In vitro experiment, the optimal concentration of artificial matrix and AG1478 were 15mM and 20mM respectively. The optimal radiation dose was 5Gy. We could confirm tumor cell were treated effectively in pathological findings. Survival analysis was better survival of the radiation group with artificial matrix than of radiation group without artificial matrix. Statistical analysis was significant different. Average of survival were 65 days and 87days respectively.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Tohoku Brain Tumor Study Group. Treatment outcomes in glioblastoma patients aged 76 years or older : a multicenter retrospective cohort study2014
Author(s)
Uzuka T, Asano K, Sasajima T, Sakurada K, Kumabe T, Beppu T, Ichikawa M, Kitanaka C, Aoki H, Saito K, Ogasawara K, Tominaga T, Mizoi K, Ohkuma H, Fujii Y, Kayama T
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Journal Title
J Neurooncol
Volume: 116
Pages: 299-306
Related Report
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[Journal Article] DNA mismatch repair protein (MSH6) correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide : the national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors2013
Author(s)
Hirohata T, Asano K, Ogawa Y, Takano S, Amano K, Isozaki O, Iwai Y, Sakata K, Fukuhara N, Nishioka H, Yamada S, Fujio S, Arita K, Takano K, Tominaga A, Hizuka N, Ikeda H, Osamura RY, Tahara S, Ishii Y, Kawamata T, Shimatsu A, Teramoto A, Matsuno A.
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Journal Title
J Clin Endocrinol Metab
Volume: 98
Pages: 1130-1136
Related Report
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[Journal Article] DNA mismatch repair protein (MSH6) correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide: the national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors.2013
Author(s)
Hirohata T, Asano K, Ogawa Y, Takano S, Amano K, Isozaki O, Iwai Y, Sakata K, Fukuhara N, Nishioka H, Yamada S, Fujio S, Arita K, Takano K, Tominaga A, Hizuka N, Ikeda H, Osamura RY, Tahara S, Ishii Y, Kawamata T, Shimatsu A, Teramoto A, Matsuno A.
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Journal Title
J Clin Endocrinol Metab
Volume: 98
Pages: 1130-1136
Related Report
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