| Project/Area Number |
23592114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIN Masahiro 東京大学, 医学部附属病院, 講師 (70302726)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 脳・神経 / 脳神経疾患 / 神経科学 / 痴呆 / 臨床 / 脳深部刺激療法 |
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| Outline of Final Research Achievements |
Amyloid β oligomer was stereotactically injected into cerebral cortex and basal nucleus of Mynert (BNM) in the elderly rats. Subjects were divided into 3 groups, the Control group (surgery-,injection-), the Sham group (surgery+,injection-), and Aβ group (surgery+,injection-), and their cognitive functions were evaluated before and after surgery with Morris’s Water Maze. The brains in each group were extracted and degeneration of the cholinergic neurons were evaluated with immunostaining method.
As results, in the rats in the injection + groups, cognitive function was significantly more deteriorated than those in the injection -group. However, histological investigation of the cholinergic neurons in BNM revealed that the neuronal degeneration of the cholinergic neurons tended to be more severe in BNM of the rats in the injection + group than observed in the nucleus of the rats in the injection -group, which was not statistically significant.
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