Mechanism of glioma invasion and its inhibition
| Project/Area Number |
23592118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Fukui |
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Principal Investigator |
KITAI Ryuhei 福井大学, 医学部, 准教授 (80251990)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Glioma / Brain tumor / Invasion / Detection / グリオーマ / 浸潤先端 / ５ＡＬＡ / サイトカイン / 脳腫瘍 |
|---|
| Research Abstract |
The motility of cultured glioma cells were estimated by video monitor. The glioma cell line A172 was the most moving cells in other cells such as U87, T98G and primary glioma cell culture. The cells stimulated by low Oxygen chamber and low pH showed initial cell halt and following high motility. The inhibition of these motility was blocked by interferon beta. As for the detection of invasion front, recently 5ALA photodynamic diagnosis was introduced in glioma surgery. Using cultured cells, the fluorescent intensity and cell density were determined. The detection limit by the operator's naked eyes was reported.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Measurement and cellular sources of the soluble interleukin-2 receptor in primary central nervous system lymphoma2013
Author(s)
Kitai R, Sasaki H, Matsuda K, Tsunetoshi K, Yamauchi T, Neishi H, Matsumura K, Tsunoda A, Takeuchi H, Sato K, Kikuta K
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Journal Title
Brain Tumor Pathol
Volume: (1)
Pages: 34-9
Related Report
Peer Reviewed
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[Journal Article] Clinicopathological features in the recurrence of oligodendroglioma and diffuse astrocytoma2012
Author(s)
Takeuchi H, Hosoda T, Kitai R, Kodera T, Arishima H, Tsunetoshi K, Neishi H, Yamauchi T, Sato K, Imamura Y, Itoh H, Kubota T, Kikuta K
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Journal Title
Brain Tumor Pathol
Pages: 140-7
Related Report
Peer Reviewed
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[Journal Article] Glioblastoma with oligodendroglial components2012
Author(s)
Takeuchi H, Hosoda T, Kitai R, Kodera T, Arishima H, Tsunetoshi K, Neishi H, Yamauchi T, Sato K, Imamura Y, Itoh H, Kubota T, Kikuta K
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Journal Title
Brain Tumor Pathol
Volume: (3)
Pages: 154-9
Related Report
Peer Reviewed
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[Journal Article] Lymphomatosis cerebri : clinical characteristics, neuroimaging, and pathological findings2012
Author(s)
Kitai R, Hashimoto N, Yamate K, Ikawa M, Yoneda M, Nakajima T, Arishima H, Takeuchi H, Sato K, Kikuta K
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Journal Title
Brain Tumor Pathol.
Volume: (1)
Pages: 47-53
Related Report
Peer Reviewed
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[Journal Article] Measurement and cellular sources of the soluble interleukin-2 receptor in primary central nervous system lymphoma.2012
Author(s)
Kitai R, Sasaki H, Matsuda K, Tsunetoshi K, Yamauchi T, Neishi H, Matsumura K, Tsunoda A, Takeuchi H, Sato K, Kikuta KI.
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Journal Title
Brain Tumor Pathol.
Volume: in press
Issue: 1
Pages: 34-39
DOI
Related Report
Peer Reviewed
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