| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
We have tried to reveal the predictive or prognostic factors on WT1 peptide vaccination against malignant gliomas. As those factors, a phenotype of memory T cells in periphera blood, high expression of WT1 mRNA, an early positive turning of DTH and methionine parametric response map (PRM) were confirmed. We have also shown that the escape phenomena from WT1 vaccination was in part due to a decrease of WT1/HLA class I molecule expression and an increase of Treg in tumor microenvironment.
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