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Transportation for spinal cord regeneration inducing angiogenesis

Research Project

Project/Area Number 23592124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

IWATSUKI Koichi  大阪大学, 医学(系)研究科(研究院), 講師 (80346204)

Co-Investigator(Kenkyū-buntansha) TOSHIKI Yoshimine  大阪大学, 大学院医学系研究科, 教授 (00201046)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords脊髄・脊椎疾患学 / 脊髄神経再生 / 骨髄間質細胞 / 嗅神経鞘細胞 / 血管内皮細胞 / 嗅粘膜 / 脊髄損傷 / 神経再生 / 血管新生 / 成長因子 / 骨髄幹細胞
Research Abstract

olfactory mucosa transplantation following spinal cord injury can support at least partial hind limb motor recovery. In this study, we identified numerous axons surrounding the transplanted cells, and penetrating the mucosa at the transplant site without marginal spinal white matter. Olfactory mucosa might therefore be a more suitable scaffold for axonal regeneration than white matter, which contains inhibiting factors for axonal regeneration in the spinal cord.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (49 results)

All 2014 2013 2012 Other

All Journal Article (22 results) (of which Peer Reviewed: 9 results) Presentation (24 results) (of which Invited: 4 results) Book (3 results)

  • [Journal Article] Primary olfactory mucosal cells promote axonal outgrowth in a three-dimensional assay2014

    • Author(s)
      Ishihara, Masahiro; Mochizuki-Oda, Noriko; Iwatsuki, Koichi et al.
    • Journal Title

      Journal of Neuroscience Research

      Volume: ahead of print Issue: 7 Pages: 270-4

    • DOI

      10.1002/jnr.23367

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence of trans-synaptic neurons derived from olfactory mucosa transplanted after spinal cord injury2014

    • Author(s)
      Takashi Moriwaki, Koichi Iwatsuki et al.
    • Journal Title

      Spine

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of olfactory mucosa as a scaffold for axonal regeneration following spinal cord contusion in rats2013

    • Author(s)
      Koichi Iwatsuki
    • Journal Title

      Neuroscience & Medicine

      Volume: 4 Pages: 112-116

    • Related Report
      2013 Final Research Report
  • [Journal Article] Involuntary muscle spasm expressed as motor evoked potential after olfactory mucosa autograft in patients with chronic spinal cord injury and complete paraplegia J2013

    • Author(s)
      Koichi Iwatsuki, Toshiki Yoshimine, Yoshiyuki Sankai, Fumihiro Tajima, Masao Umegaki, Yu-Ichiro Ohnishi, Masahiro Ishihara, Koshi Ninomiya, Takashi Moriwaki
    • Journal Title

      Biomedical Science and Engineering

      Volume: 6 Pages: 908-916

    • Related Report
      2013 Final Research Report
  • [Journal Article] ニューロサイエンスの最新情報脊髄損傷に対する自家嗅粘膜移植法2013

    • Author(s)
      吉峰俊樹、岩月幸一、田島文博
    • Journal Title

      Clinical Neuroscience

      Volume: vol. 31 Pages: 2-2

    • Related Report
      2013 Final Research Report
  • [Journal Article] 自家嗅粘膜移植による脊髄再生医療2013

    • Author(s)
      岩月幸一
    • Journal Title

      脳神経外科ジャーナル

      Volume: vol.22 No.6 Pages: 452-458

    • NAID

      10031158781

    • Related Report
      2013 Final Research Report
  • [Journal Article] 嗅粘膜移植による脊髄神経再生治療2013

    • Author(s)
      岩月幸一、吉峰俊樹、大西諭一郎、二宮貢士、森脇崇
    • Journal Title

      Peripheral Nerve

      Volume: 24(2)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 嗅粘膜移植による脊髄再生医療2013

    • Author(s)
      岩月幸一、吉峰俊樹、大西諭一郎、二宮貢士、森脇崇
    • Journal Title

      Anesthesia 21 century

      Volume: vol 15, No.3 Pages: 47-47

    • Related Report
      2013 Final Research Report
  • [Journal Article] Transplantation of olfactory mucosa as a scaffold for axonal regeneration following spinal cord contusion in rats.2013

    • Author(s)
      Koichi Iwatsuki et al.
    • Journal Title

      Neuroscience & Medicine

      Volume: 4 Issue: 02 Pages: 112-116

    • DOI

      10.4236/nm.2013.42018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involuntary muscle spasm expressed as motor evoked potential after olfactory mucosa autograft in patients with chronic spinal cord injury and complete paraplegia2013

    • Author(s)
      Koichi Iwatsuki, Toshiki Yoshimine et al.
    • Journal Title

      J. Biomedical Science and Engineering,

      Volume: 6 Issue: 09 Pages: 908-916

    • DOI

      10.4236/jbise.2013.69111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult olfactory sphere cells are a source of oligodendrocyte and Schwann cell progenitors.2013

    • Author(s)
      Ohnishi Y, Iwatsuki K et al.
    • Journal Title

      Stem Cell Research

      Volume: 11 Issue: 3 Pages: 1178-1190

    • DOI

      10.1016/j.scr.2013.08.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regenerative Medicine for Spinal Cord Injury Using Olfactory Mucosa Autograft2013

    • Author(s)
      Koichi Iwatsuki, Toshiki Yoshimine
    • Journal Title

      Springer

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transplantation of olfactory mucosa as a scaffold for axonal regeneration following spinal cord contusion in rats2013

    • Author(s)
      Koichi Iwatsuki
    • Journal Title

      Neuroscience & Medicine(NM)

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intradural extramedullary spinal ependymoma: a case report of malignant transformation occurring2013

    • Author(s)
      Takashi Moriwaki, Koichi Iwatsuki
    • Journal Title

      Asian Spine Journal

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disuse muscle atrophy exacerbates motor neuronal degeneration caudal to the site of spinal cord injury2012

    • Author(s)
      Ohnishi Y, Iwatsuki K, Shinzawa , Nakai Y, Ishihara M, Yoshimine T
    • Journal Title

      Neuroreport

      Volume: 15,23(3) Pages: 157-61

    • Related Report
      2013 Final Research Report
  • [Journal Article] 脊髄損傷に対する再生療法の展望2012

    • Author(s)
      岩月幸一
    • Journal Title

      脳神経外科ジャーナル

      Volume: vol.20, No.8 Pages: 580-584

    • Related Report
      2013 Final Research Report
  • [Journal Article] 慢性期脊髄損傷に対する自家嗅粘膜移植法2012

    • Author(s)
      岩月幸一、吉峰俊樹、梅垣昌士、大西諭一郎、森脇崇
    • Journal Title

      Bone Jint Nerve

      Volume: vol.1, No.3 Pages: 569-576

    • Related Report
      2013 Final Research Report
  • [Journal Article] 嗅粘膜による脊髄再生2012

    • Author(s)
      岩月幸一
    • Journal Title

      総説Clinical Neuroscience

      Volume: Vol.30 Pages: 1111-1114

    • Related Report
      2013 Final Research Report
  • [Journal Article] 自家嗅粘膜移植による脊髄再生医療2012

    • Author(s)
      岩月幸一
    • Journal Title

      日整会誌

      Volume: 86 Pages: 897-902

    • NAID

      10031158781

    • Related Report
      2013 Final Research Report
  • [Journal Article] Entrapment of the Fifth Lumbar Spinal Nerve by Advanced Osteophytic Changes of the Lumbosacral Zygapophyseal Joint: A Case Report.2012

    • Author(s)
      Yu-ichiro Ohnishi, Takamichi Yuguchi, Koichi Iwatsuki, Toshiki Yoshimine.
    • Journal Title

      Asian Spine Journal.

      Volume: 4 Issue: 4 Pages: 291-3

    • DOI

      10.4184/asj.2012.6.4.291

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adult Olfactory Sphere Cells are a Source of Oligodendrocyte and Schwann Cell Progenitors Stem Cell

    • Author(s)
      Yu-ichiro Ohnishi,Koichi Iwatsuki,Koshi Ninomiya, Takashi Moriwaki, Toshiki Yoshimine
    • Journal Title

      Research

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Primary olfactory mucosal cells promote axonal outgrowth in a three-dimensional assay

    • Author(s)
      Ishihara, Masahiro; Mochizuki-Oda, Noriko; Iwatsuki, Koichi; Kishima, Haruhiko; Ohnishi, Yu-ichiro; Moriwaki, Takashi; Umegaki, Masao; Yoshimine, Toshiki
    • Journal Title

      Journal of Neuroscience Research

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄損傷に対する革新的治療法開発の現状と展望2014

    • Author(s)
      岩月幸一
    • Organizer
      TRI 10周年記念シンポジウム
    • Place of Presentation
      東京JA共済ビル
    • Year and Date
      2014-01-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 嗅粘膜ラットを用いた移植組織由来trans-synaptic neuronsの存在の検討2014

    • Author(s)
      森脇崇、岩月幸一他
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] オルファクトリースフィア細胞による中枢末梢神経損傷治療の検討2014

    • Author(s)
      大西諭一郎、岩月幸一他
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性期脊髄損傷に対する自家嗅粘膜移植2014

    • Author(s)
      岩月幸一他
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 嗅粘膜移植による脊髄神経再生治療2013

    • Author(s)
      岩月幸一
    • Organizer
      第24回日本末梢神経学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2013-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄損傷の再生医療:自家嗅粘膜移植による損傷脊髄機能再生法2013

    • Author(s)
      岩月幸一
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Bucharest Romania Complete paraplegia patient in chronic spinal cord injury with involuntary muscle spasm expressed motor evoked potential after olfactory mucosa autograft2013

    • Author(s)
      Koichi Iwatsuki
    • Organizer
      IANR international Association of Neurorestoratology 6
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経再生医療とリハビリテーション自家嗅粘膜移植による損傷脊髄機能再生法2013

    • Author(s)
      岩月幸一
    • Organizer
      第54回日本神経学会学術大会東京国際フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] オルファクトリースフィア細胞による中枢・末梢神経損傷治療の検討2013

    • Author(s)
      大西諭一郎、岩月幸一、新沢康英、二宮貢士、森脇崇、貴島晴彦、吉峰俊樹
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 嗅粘膜移植による脊髄軸索再建のWGAを用いた検討2013

    • Author(s)
      森脇崇、岩月幸一、大西諭一郎、二宮貢士、貴島晴彦、梅垣昌士、石原正浩、吉峰俊樹
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Breakfast session Involuntary muscles spasm expressed as motor evoked potential after olfactory mucosa autograft in patients with chronic spinal cord injury and complete paraplegia2013

    • Author(s)
      Koichi Iwatsuki
    • Organizer
      15 ^<th> World congress of neurosurgery
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Involuntary Muscles Spasm Expressed as Motor Evoked Potential after Olfactory Mucosa Autograft in Patients with Chronic Spinal Cord Injury and Complete Paraplegia2013

    • Author(s)
      Koichi Iwatsuki
    • Organizer
      BIT's 6^<th> Annual World Congress of Regenerative Medicine & Stem cells
    • Place of Presentation
      Dalian, China
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄損傷慢性期に対する自家嗅粘膜移植術2013

    • Author(s)
      岩月幸一
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄損傷ラットに対する嗅粘膜移植における移植片由来interneuronの軸索再建への関与2013

    • Author(s)
      森脇崇、岩月幸一等
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性期完全脊髄損傷に対する嗅粘膜移植法2013

    • Author(s)
      岩月幸一、吉峰俊樹、大西諭一郎、二宮貢士、森脇崇
    • Organizer
      第48回日本脊髄障害医学会
    • Place of Presentation
      アクロス福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Complete paraplegia patient in chronic spinal cord injury with involuntary muscle spasm expressed motor evoked potential after olfactory mucosa autograft2013

    • Author(s)
      Koichi Iwatsuki
    • Organizer
      international Association of Neurorestoratology 6
    • Place of Presentation
      Bucharest Romania
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involuntary muscles spasm expressed as motor evoked potential after olfactory mucosa autograft in patients with chronic spinal cord injury and complete paraplegia2013

    • Author(s)
      Koichi Iwatsuki
    • Organizer
      15th World congress of neurosurgery
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Involuntary Muscles Spasm Expressed as Motor Evoked Potential after Olfactory Mucosa Autograft in Patients with Chronic Spinal Cord Injury and Complete Paraplegia2013

    • Author(s)
      Koichi Iwatsuki
    • Organizer
      BIT’s 6th Annual World Congress of Regenerative Medicine & Stem cells
    • Place of Presentation
      Dalian, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経再生医療とリハビリテーション 自家嗅粘膜移植による損傷脊髄機能再生法2013

    • Author(s)
      岩月幸一
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脊髄損傷の再生医療:自家嗅粘膜移植による損傷脊髄機能再生法2013

    • Author(s)
      岩月幸一
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Olfactory mucosal transplantation in spinal cord injury The annual conference of neuro spinal surgeons association2012

    • Author(s)
      Koichi Iwatsuki
    • Organizer
      Spine2012
    • Place of Presentation
      India
    • Related Report
      2012 Research-status Report
  • [Presentation] 脊髄脊椎外科の課題 脊髄損傷の再生医療2012

    • Author(s)
      岩月幸一、他
    • Organizer
      第32回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット脊髄損傷における軸再生のための足場としての嗅粘膜の有用性2012

    • Author(s)
      岩月幸一、吉峰俊樹、梅垣昌士、大西諭一郎、森脇 崇
    • Organizer
      第27回日本脊髄外科学会
    • Place of Presentation
      浦安
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性期脊髄損傷に対する自家嗅粘膜移植法2012

    • Author(s)
      岩月幸一、梅垣昌士,大西諭一郎、森脇 崇、二宮貢士、吉峰俊樹
    • Organizer
      第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Book] Cybernics: Fusion of human, machine and information systems2014

    • Author(s)
      Koichi Iwatsuki et al.
    • Total Pages
      10
    • Publisher
      Springer Verlag
    • Related Report
      2013 Annual Research Report
  • [Book] 先進医療NAVIGATOR編集先進医療フォーラム第2章先進医療治療の実際2013

    • Author(s)
      梅垣昌士、岩月幸一、吉峰俊樹
    • Publisher
      日本医学出版東京
    • Related Report
      2013 Final Research Report
  • [Book] 脊椎脊髄外科サージカル・テクニック2012

    • Author(s)
      今栄信治、岩月幸一
    • Total Pages
      312
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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