Transportation for spinal cord regeneration inducing angiogenesis
Project/Area Number |
23592124
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cerebral neurosurgery
|
Research Institution | Osaka University |
Principal Investigator |
IWATSUKI Koichi 大阪大学, 医学(系)研究科(研究院), 講師 (80346204)
|
Co-Investigator(Kenkyū-buntansha) |
TOSHIKI Yoshimine 大阪大学, 大学院医学系研究科, 教授 (00201046)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 脊髄・脊椎疾患学 / 脊髄神経再生 / 骨髄間質細胞 / 嗅神経鞘細胞 / 血管内皮細胞 / 嗅粘膜 / 脊髄損傷 / 神経再生 / 血管新生 / 成長因子 / 骨髄幹細胞 |
Research Abstract |
olfactory mucosa transplantation following spinal cord injury can support at least partial hind limb motor recovery. In this study, we identified numerous axons surrounding the transplanted cells, and penetrating the mucosa at the transplant site without marginal spinal white matter. Olfactory mucosa might therefore be a more suitable scaffold for axonal regeneration than white matter, which contains inhibiting factors for axonal regeneration in the spinal cord.
|
Report
(4 results)
Research Products
(49 results)