Combination therapy of oncolytic virus & antiangiogenic drug for malignant glioma
Project/Area Number |
23592125
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Koji 岡山大学, 医歯薬学総合研究科, 准教授 (40294467)
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Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 医歯薬学総合研究科, 教授 (70236785)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 脳腫瘍学 / 腫瘍溶解性ウイルス / cilengitide / 分子標的薬 / Cilengitide |
Research Abstract |
Oncolytic viral (OV) therapy has been considered as a promising treatment modality for brain tumors. Vasculostatin, the fragment of brain-specific angiogenesis inhibitor-1, shows anti-angiogenic activity against malignant gliomas. Previously, a vasculostatinexpressing oncolytic herpes simplex virus-1, Rapid Antiangiogenesis Mediated By Oncolytic virus (RAMBO), was reported to have a potent antitumor effect. Here, we investigated the therapeutic efficacy of RAMBO and cilengitide, an integrin inhibitor, combination therapy for malignant glioma. In vitro, RAMBO, combined with cilengitide, induced synergistic cytotoxicity on glioma cells. In vivo, there was a significant increase in the survival of mice treated with combination therapy compared with RAMBO or cilengitide monotherapy. These results indicate that cilengitide enhanced vasculostatinexpressing OV therapy for malignant glioma and provide a rationale for designing future clinical trials combining these two agents.
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Report
(4 results)
Research Products
(177 results)
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[Presentation] 2013.07.05 Induction of an angiogenec factor, CYR61, in oncolytic viral therapy for malignant gliomas2013
Author(s)
Kurozumi K , Ichikawa T , Fujii K , Shimazu Y , Onishi M , Ishida J , Chiocca EA , Kaur B , Date I
Organizer
第19回日本遺伝子治療学会年次学術集会(The 19th Annual Meeting of Japan Society of Gene Therapy)
Place of Presentation
岡山
Year and Date
2013-07-05
Related Report
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[Presentation] Multiple mechanisms of cilengitide treatment for malignant glioma2012
Author(s)
33. :, 2012.04.20-22 Kurozumi K , Ichikawa T , Onishi M , Fujii K , Shimazu Y , Ishida J , Chiocca EA , Kaur B , Date I
Organizer
The 9th Meeting of Asian Society for Neuro-Oncology
Place of Presentation
Taipei, Taiwan
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[Presentation] Induction of an angiogenec factor, CYR61, in oncolytic viral therapy for malignant gliomas
Author(s)
Kurozumi K , Ichikawa T , Fujii K , Shimazu Y , Onishi M , Ishida J , Chiocca EA , Kaur B , Date I
Organizer
第19回日本遺伝子治療学会年次学術集会(The 19th Annual Meeting of Japan Society of Gene Therapy)
Place of Presentation
岡山
Related Report
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[Presentation] Cilengitide, integrin inhibitor, enhances anti-glioma efficacy of vasculostatin-expressing oncolytic virus
Author(s)
Shimazu Y , Fujii K , Kurozumi K , Ichikawa T , Onishi M, Ishida J , Chiocca EA, Kaur B , Date I
Organizer
XV WFNS World Congress of Neurosurgery (WFNS 2013)
Place of Presentation
Seoul, Korea
Related Report
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[Presentation] Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma
Author(s)
Ichikawa T , Onishi M , Kurozumi K), Maruo T , Fujii K , Ishida J , Shimazu Y, Oka T, Chiocca EA , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A
Related Report
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[Presentation] Proteomic analysis of invasion - and angiogenesis - related proteins in malignant gliomas
Author(s)
Takahashi Y , Ichikawa T , Maruo T , Kurozumi K, Onishi M , Ouchida M , Fujii K , Shimazu Y , Oka T , Chiocca EA , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A
Related Report
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[Presentation] Multimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models
Author(s)
Umakoshi M , Ichikawa T , Kurozumi K , Onishi M , Fujii K , Ishida J , Shimazu Y , Oka T , Chiocca EA , Kaur B , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A
Related Report
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[Presentation] Analysis of combination therapy of the adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) and the integrin antagonist cilengitide
Author(s)
Shimazu Y , Kurozumi K , Ichikawa T , Fujii K , Onishi M , Ishida J , Oka T , Watanabe M , Nasu Y , Kumon H , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A
Related Report
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