Suppressive control of glioma invasions via inhibition of sodium ion/proton exchanger 1
| Project/Area Number |
23592130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
YANO Hajime 愛媛大学, 医学(系)研究科(研究院), 准教授 (00284414)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経膠腫 / 潜行性浸潤 / ナトリウムイオン/プロトン交換輸送体１ / EIPA / TGFbeta シグナル / ナトリウム/プロトン交換輸送体１ / 血管新生 / TGFbeta / 扁平上皮がん / リンパ節転移 / NHE1 / グリオーマ / マイクログリア / 脳マクロファージ / 活性酸素 / 臨床検体 |
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| Research Abstract |
Preclinical evaluations for the development of a novel anti-tumor invasion medicine by utilization of 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) which had exhibited promising potential in vitro were performed, aiming at developing a novel powerful therapy against gliomas of which treatment has long been unimproved. On the way of the explorations of modes of action of EIPA, a characteristic blood vessel was found to contribute to the glioma cell invasions, and an implication that activation process of TGFbeta1 may participate in this step was obtained. Furthermore, the validity to consider EIPA as an anti-tumor invasion medicine was confirmed from the observation of contributions of the target of EIPA sodium ion/proton exchanger1 (NHE1) on lymph node metastasis of head and neck squamous cell carcinoma cells (SCC). Highly metastatic subline-cell of a SCC acquired enhanced expression of NHE1 compared with the non-metastatic parental cell line, and knockdown of NHE1 reduced the metastasis.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β12013
Author(s)
Sugimoto, K., Nishioka, R., Ikeda, A., Mise, A., Takahashi, H., Yano, H., Kumon, Y., Ohnishi, T., and Tanaka, J
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Journal Title
Glia
Volume: 62
Pages: 185-198
Related Report
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[Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013
Author(s)
N., Tanaka, J., Sugimoto, K., Nishihara, T., Nishioka, R., Takahashi, H., Yano, H., Matsumoto, S., Ohue, S., Watanabe, H., Kumon, T., and Ohnishi, T. J. Neurosci
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Journal Title
Tei Res
Volume: 91
Pages: 681-693
Related Report
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[Journal Article] Oct3/4 promotes migration and invasion of glioblastoma cells2012
Author(s)
Kobayashi, K., Takahashi, H., Inoue, A., Harada, H., Toshimori, S., Kobayashi, Y., Goto, K., Sugimoto, K., Yano, H., Ohnishi, T., and Tanaka, J
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Journal Title
J. Cell. Biochem
Volume: 113
Pages: 508-517
Related Report
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[Journal Article] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes2012
Author(s)
Mayorca-Guiliani, A, E., Yano, H., Nakashiro, K., Hamakawa, H., and Tanaka, J
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Journal Title
Oral Oncology
Volume: 48
Pages: 663-758
Related Report
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