| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Nucleolar stress response is a newly identified mechanism which regulates tumor suppressor p53 protein. We previously identified PICT1 as a novel key regulator of nucleolar stress response. In the present study, we investigated tumor regulatory function of PICT1. We found reduced PICT1 expression decreased cancer cell growth and accumulated p53. In addition, we showed low PICT1 expression associated with better prognosis in cancer patients. These observation suggested that the nucleolar stress response PICT1 regulates could play a definitive role in tumor suppression and, chemicals which induce nucleolar stress response might be attractive cancer therapeutics. Then, we next constructed a reporter system to visualize and quantitate nucleolar stress response. We found that this reporter system allowed quantitative measurement with excellent accuracy. This reporter system may lead to identify novel cancer therapeutics.
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